Choosing Between Initial ART Options: Answering the Questions

CCO Infectious Disease Podcast

In this episode, Marta Boffito, MD, PhD, FRCP, and Michelle Cespedes, MD, MS, discuss initial ART options, including:

• Recommended first-line ART options for most PWH according to DHHS, IAS-USA, EACS, BHIVA, and WHO guidelines
• Data for weight gain after ART initiation with different ARV classes and drugs
• Weight gain disparities by race and gender after ART initiation
• Data from the RESPOND study including risk factors for weight gain and CV event risk with INSTI vs non-INSTI–based ART
• The impact of INSTIs on CV events in the Swiss HIV Cohort study
• Recommendations for ART and contraception for PWH of childbearing potential
• Drug–drug interactions between first-line ART and contraceptive options
• Guideline-recommended first-line ART options in pregnancy with a discussion of how these regimens differ from those recommended for most PWH

Marta Boffito, MD, PhD, FRCP
Consultant Physician
Clinical Director, HIV, Sexual and Gender Health, Dermatology
Chelsea and Westminster Hospital NHS Foundation Trust
Imperial College London
London, United Kingdom

Michelle Cespedes, MD, MS
Professor of Medicine
Division of Infectious Disease
Department of Medicine
Icahn School of Medicine at
Mount Sinai
New York, New York

Link to full program: bit.ly/3HPu4Lk