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In the sixth episode of The new frontier podcast, we're joined by Catherine Vrentas, Life Sciences Lead at Booz Allen Hamilton (VA, USA). Cathy explains how biomarkers can be used to predict the therapeutic outcome and efficacy of CGTs and the biomarkers in particular that have shown strong predictive value. We delve into the common challenges of w…
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We caught up with Principal Scientist Lindsay Denhoff (ICON; Dublin, Ireland) to discuss immunogenicity considerations for therapeutic proteins and the current analytical methodologies for detecting and characterizing anti-drug antibodies (ADAs). Lindsay shares some industry best practices for achieving high-quality ADA assays, as well as some of t…
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In this Tech Blast episode supported by Sartorius (Göttingen, Germany), we speak with David Apiyo – Manager of Applications Development at Sartorius (MN, USA) – about epitope binning, why it's performed and the best ways to conduct it. Plus, learn more about Sartorius' biolayer interferometry platforms and their application in epitope binning.…
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In this interview, we spoke to John Chappell, Senior Global Scientific Support Manager at Gyros Protein Technologies (Uppsala, Sweden) about his experience working with the Gyrolab platform for oligonucleotide assays. John discusses the advantages of using Gyrolab for oligo quantification in biological fluids and shares his thoughts on the next ste…
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In the fifth episode of The New Frontier podcast, we're joined by Paul Byrne, Senior Director of Genomics from ProtaGene (MA, USA). Paul describes his experience working with qPCR vs digital and digital droplet PCR assays and advises on their pros and cons, as well as when it's best to use each. We discuss how these assays can be optimized for cell…
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In this episode of The New Frontier podcast, we're joined by Daniel Schulz-Jander, Senior Director of Mass spectrometry Bioanalysis at QPS Netherlands (Groningen). Daniel explains how he uses immune-precipitation and immunoaffinity LC–MS techniques for his work relating to macromolecular pharmaceuticals like gene therapies, as well as their benefit…
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What disparities exist in cancer screening and how does this impact patient outcomes? Listen to our latest podcast episode with Kilan Ashad-Bishop (American Cancer Society) to find out about the intersection between science, health, and society.Kirjoittanut Taylor & Francis Group
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In this episode, we spoke to Senior Director Johanna Mora about her experience with immunogenicity testing for cell and gene therapies (CGTs) and how she prepared for the expansion of BMS's portfolio to include CGTs. We discuss the importance of having diverse teams with a broad range of experiences to solve complex problems, as well as the role of…
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In the first episode of this series, we spoke to Executive Director and Global Head of Regulatory Services Kimberley Buytaert-Hoefen about her experience with cell and gene therapy (CGT) approvals and the barriers to getting these important therapeutics to the patient. Kim advises early regulatory interaction and collaboration to improve the succes…
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In our new podcast series, we're joined by a Bioanalysis author to review their publication's biggest challenges, wider implications and next steps. In the final episode of series one, we're joined by Hetal Sarvaiya and Yuting Wang from AbbVie (MA, USA), who talk about the challenges of having an international team working on their perspective arti…
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In this Tech Blast episode supported by Sartorius, we speak with Derrick Christopher Campos, Product Manager at Sartorius (TX, USA), about Surface Plasmon Resonance (SPR). This tried-and-true technique allows researchers to do label-free protein characterization; in this podcast, Derrick discusses how Sartorius improves upon multi-cycle kinetics wi…
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In our new podcast series, we're joined by a Bioanalysis author to review their publication's biggest challenges, wider implications and next steps. In episode four, we're joined by Senior Scientist and Technical Specialist Ashley Phillips. Ashley's publication assessed the performance of next-generation trypsins for rapid protein LC-MS bioanalysis…
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In our new podcast series, we're joined by a Bioanalysis author to review their publication's biggest challenges, wider implications and next steps. In episode three, Digital Editor Ellen Williams is joined by Clinical Instructor and Education Coordinator Camilla Linder and Biomedical Laboratory Scientist Miguel Gambell Barroso. The collaborative p…
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In this episode of Talking Techniques, Ritwika Biswas, Field Scientist at Sino Biological US Inc. (PA, USA), walks us through the chimeric antigen receptor (CAR) development process and how T and natural killer (NK) cells can be utilized to carry these modular synthetic molecules. Ritwika also addresses the safety and efficacy of these cell therapi…
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In this Tech Blast episode, we explore preparing 3D cell cultures with Sartorius’ (Goettingen, Germany) Sandra Söderholm, Application Development Specialist, and Maria Voutilainen, Product Manager. Sandra and Maria give us an introduction to 3D cell cultures and how to prepare them, and then delve into a foundational technique that is often overloo…
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In our new podcast series, we're joined by a Bioanalysis author to review their publication's biggest challenges, wider implications and next steps. In episode two, Ellen is joined by Research Assistant Gaudry Troché to discuss conventional sampling and microsampling for the comparison of pharmacokinetic study profiles of insulin. Gaudry discusses …
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In this episode of Talking Techniques, Ritwika Biswas, Field Scientist at Sino Biological US Inc., walks us through the chimeric antigen receptor (CAR) development process and how T and natural killer (NK) cells can be utilized to carry these modular synthetic molecules. Ritwika also addresses the safety and efficacy of these cell therapies as well…
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In this episode, supported by Fortis Life Sciences, we delve into the relationship between mitochondria, inflammation and cancer, discussing the new techniques that are bearing fruit in this field, such as spatial analysis.Our expert insight for this episode comes from Phillip West, Principle Investigator of the West lab at Texas A&M Medicine (TX, …
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In this Tech Blast episode supported by CN Bio (Cambridge, UK), their Lead Scientist Emily Richardson and Principal Bioengineer Dharaminder Singh talk us through organ-on-a-chip (OOC) technologies. From what they are and how they work to what kind of data they provide and their future applications, Emily and Dharaminder provide all the information …
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In our new podcast series, we're joined by a Bioanalysis author to review the publication's biggest challenges, wider implications and next steps. In this first episode, we're joined by early career Researcher Anthony Breton to discuss volumetric absorptive microsampling (VAMS®) as an alternative to venepuncture for the assessment of essential and …
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In this episode, sponsored by Zymo Research, we explore the microbiome and how long-read sequencing techniques are changing our approach to the field and the exciting discoveries that they have led to. To do this we speak to Kris Locken, Molecular Biologist in the Research & Development department of Zymo Research (CA, USA), and Jeremy Wilkinson, G…
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In this Tech Blast episode supported by Thermo Fisher Scientific (MA, USA), Associate Product Manager Jon Flasher talks us through gene expression analysis, some of its challenges and the tools available to streamline the process. Listen to learn more about how Thermo's TaqMan Gene Expression Assays can be used to address research questions around …
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Hello and welcome to the latest episode of OCTalks, the podcast series from Oncology Central. I am Jade Parker, Senior Editor of Oncology Central. Today I am joined by Heather Beasley who is a post-doctoral scholar at Vanderbilt University (TN, USA). Heather’s research focuses on calcium signaling in breast cancer, as well as the dysregulation of b…
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This episode, our second recorded at Neuroscience 2022 (13-19th April 2022; San Diego, CA, USA), delves into the importance of open data in neuroscience and the FAIR guidelines, which encourage researchers to make their data Findable, Accessible, Interoperable and Reusable.Sharing her considerable expertise in this area is one of the authors of the…
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In this Tech Blast episode, we discuss lab automation with Gregory Lee, Automation Manager at Zymo Research (CA, USA). We explore the types of tasks that can be automated, Greg’s three Ts to consider when thinking about automation ¬– technical, throughput and turnaround time – and his top tips for implementing automation. Greg also shares common pi…
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In this episode of Talking Techniques, we head to the Ecuadorian rainforest to chat about the use of sequencing in conservation with Zane Libke, a field researcher based at Sumak Kawsay In Situ (Pastaza, Ecuador). Zane discusses how he turned his fascination with nature into a career, his current work using nanopore sequencing technologies to find …
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In this special episode of Talking techniques, one of two recorded at Neuroscience 2022, we speak to Tim Harris (Howard Hughes Medical Institute, VA, USA). Tim is the creator of Neuropixels, neural recording probes inserted into the brains of animal models, which allow researchers to collect signals from hundreds of individual neurons in different …
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Hello and welcome to the latest episode of OC Talks, the podcast from Oncology Central. I am Jade Parker, Senior Editor of Oncology Central. Today I am joined by Laetitia Decroix Guilloux, Vice President of Oncology and EMEA Commercial Strategy Lead at Janssen, to discuss the patient journey through lung cancer, examine the lung cancer paradigm, an…
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In this Tech blast episode, we talk CAR-T cell development for cancer immunotherapies with Ritwika Biswas, Product Scientist for Sino Biological. We cover some of the latest developments in the field, the advantages of CAR-T over other immunotherapies and selecting the perfect CAR-T antigen, amongst a whole host of different aspects in the field. C…
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In this interview we explore what minimal residual disease (MRD) is in hematological malignancies and how MRD is currently monitored. The interviewees also explain their recent research published in Nanomedicine, which investigates a novel tool to monitor hematological malignancies.Kirjoittanut Taylor & Francis Group
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