Healthspan podcastit

In this episode Dr Newman talks the ITP lifespan trials that used butanediol but did not see a significant result. He covers what might have caused this and some of the chemistry behind butanediol and butyrate. Dr John Newman is a professor at the Buck Institute and at University of California, San Francisco. He hopes to translate what we are learn…

@michaelsalzle Metformin and it’s effect on the hallmarks of aging https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965502/#abstract-1title

In this episode Dr Newman talks ways of boosting ketones through ketone supplements, what the different types are and what has been seen with them in human trials. Dr John Newman is a professor at the Buck Institute and at University of California, San Francisco. He hopes to translate what we are learning of the pathways that control aging into the…

In this episode Dr Newman talks about experiments that he and other teams have run on mice lifespan and healthspan while they were on ketogenic diets. Dr John Newman is a professor at the Buck Institute and at University of California, San Francisco. He hopes to translate what we are learning of the pathways that control aging into therapies to imp…

In this episode Dr Newman discusses ketones and their impact on aging. Dr John Newman is a professor at the Buck Institute and at University of California, San Francisco. He hopes to translate what we are learning of the pathways that control aging into therapies to improve the health and independence of older adults. His research at the Buck studi…

In this episode Dr Davidsohn discusses the next generation therapies that Rejuvenate Bio are working on. We also discuss, klotho, RJB02 and his personal protocol. Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases. Rejuvenate Bio website https://w…

In this episode Dr Davidsohn discusses taking RJB01 to trial with humans for a rare heart disease and how gene therapy is viewed by the FDA. Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases. Rejuvenate Bio website https://www.rejuvenatebio.com/ …

In this episode Dr Davidsohn discusses how the gene therapy helps with heart health and is only required one time. Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases. Rejuvenate Bio website https://www.rejuvenatebio.com/ Dr Davidsohn's paper menti…

In this episode Dr Davidsohn talks about the first therapy Rejuvenate Bio is working on which restores a more youthful protein expression in the liver which then impacts the rest of the body. Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases. Rej…

In this episode we discuss some of Dr Davidsohn's background, the mission of Rejuvenate Bio and the gene therapy that was developed at Dr Church's lab and is now being used to treat companion dogs. Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related disease…

@michaelsalzle. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965502/#abstract-1title

@michaelsalzle. In this episode, learn about how to keep your muscle and blood young, circadian rhythm, bifidobacterium, butyrate, akkermansia, and keeping a strong gut lining.

In this episode Dr Verburgh talks about his personal longevity protocol. Nutrigerontology: why we need a new scientific discipline to develop diets and guidelines to reduce the risk of aging-related diseases And is available here: https://pubmed.ncbi.nlm.nih.gov/25470422/ Dr Kris Verburgh is a medical doctor and researcher at the Free University of…

In this episode Dr Verburgh talks about his theory of aging and why he thinks that epigenetic dysregulation is the most fundamental of the hall marks. Nutrigerontology: why we need a new scientific discipline to develop diets and guidelines to reduce the risk of aging-related diseases And is available here: https://pubmed.ncbi.nlm.nih.gov/25470422/…

In this episode Dr Verburgh talks about his thoughts on the escape velocity of aging and what it might mean for humanity. Nutrigerontology: why we need a new scientific discipline to develop diets and guidelines to reduce the risk of aging-related diseases And is available here: https://pubmed.ncbi.nlm.nih.gov/25470422/ Dr Kris Verburgh is a medica…

In this episode Dr Verburgh talks about developments in using mobile phones as a diagnostic device. Dr Kris Verburgh is a medical doctor and researcher at the Free University of Brussels where his focus is the aging process, metabolism and nutrition. He published his first book when he was 16 and his latest is the Longevity Code. Dr Verburgh is a c…

In this episode Dr Verburgh talks about some of the upcoming technologies which will impact the longevity space in the coming years, including improvements in gene editing and epigenetics. Dr Kris Verburgh is a medical doctor and researcher at the Free University of Brussels where his focus is the aging process, metabolism and nutrition. He publish…

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In this episode Dr Verburgh talks about how to optimise our micronutrient intake. This is not simple as it is sometimes difficult to know whether you have sufficient of certain micronutrients just by looking at the blood. Dr Kris Verburgh is a medical doctor and researcher at the Free University of Brussels where his focus is the aging process, met…

@michaelsalzle. https://www.cell.com/cell/fulltext/S0092-8674(22)01570-7 a link to David Sinclair’s new paper I referenced in this episode

In this episode Dr Verburgh talks what are the key elements of a longevity diet. Dr Verburgh first wrote a paper on this subject in 2015, which introduced the term Nutrigerontology. The paper is: Nutrigerontology: why we need a new scientific discipline to develop diets and guidelines to reduce the risk of aging-related diseases And is available he…

In this episode Dr Verburgh talks about his three (well, he cheats a bit and squeezes in 5!) supplements for aging. Dr Kris Verburgh is a medical doctor and researcher at the Free University of Brussels where his focus is the aging process, metabolism and nutrition. He published his first book when he was 16 and his latest is the Longevity Code. Dr…

In this episode Dr Verburgh talks about the founding of NOVOS and why NMN was their choice for the NAD booster Dr Kris Verburgh is a medical doctor and researcher at the Free University of Brussels where his focus is the aging process, metabolism and nutrition. He published his first book when he was 16 and his latest is the Longevity Code. Dr Verb…

@michaelsalzle in this episode I discuss the best supplements for athletic performance, the different types of protein, creatine, inositol, Amino Acids, caffeine, etc.

In this episode Dr Naiman talks about the three forms of exercise, walking, resistance and cardio, trading intensity for duration and the importance of VO2max. Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused…

In this episode Dr Naiman talks about metabolic health and how it is the same thing as body composition and what we can do to have the best metabolic health. Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused o…

Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused on the practical implementation of diet and exercise for health optimization. He is the author of ‘The PE Diet’. In the book Dr Naiman explains the protein to …

In this episode Dr Naiman talks how protein is absorbed into the body, what would be a good eating pattern and the difference between plant and animal proteins. Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focuse…

In this episode Dr Naiman talks about how mTOR is activated and why our metabolic health is of much greater importance than the amount of protein that we eat. Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused …

In this episode Dr Naiman provides a more practical view on the PE Diet. What P:E ratio we should aim for, what is an optimal protein intake and how to find the P:E ratio for various foods. Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research an…

@michaelsalzle. Learn more about obesity, weight loss, hormones, calories in vs. calories out, importance of protein in muscle sparing, and metabolic rates

In this episode Dr Naiman talks about his personal journey through various diets to his formulation of the PE Diet. Dr Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused on the practical implementation of diet and …

In this episode Dr Cohen talks about the current interventions that he sees as having the most potential but also about the need for precision medicine as there are many causes for Alzheimer's, diabetes etc. and to treat the disease we need to understand the underlying cause. This also would involve changes in the way trials are run, to be able to …

In this video Dr Cohen talks CohBar, a company that he co-founded with Professor Nir Barzilai and some of the work they are doing, as well as the latest developments in his lab. He also discusses the need for precision medicine in addressing diseases of aging. Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called S…

In this video Dr Cohen talks about how mitochondria age and how they are not all the same but different in each tissue. Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called SHMOOSE https://www.nature.com/articles/s41380-022-01769-3 Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology.…

In this episode Dr Cohen talks about humanin, SHLEP2 and MTOS-c, how these impact our health, how this varies with ethnicity and age. Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitochondria-derived peptides and their possible therapeutic benefits for diabetes, Alzhe…

In this episode Dr Cohen talks about SHMOOZE a new MDP that his lab has discovered and recently published a paper on. He also discusses SNPs, mutations in the MOTS-c and Humanin genome which impacts their peptides with knock on effects on diabetes and cognitive decline. Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontol…

In this episode Dr Cohen talks about mitochondria, the discovery of the peptides they create and some of the benefits that they provide. It seems that the micro-proteins are also not only restricted to the mitochondria and are also made in the nucleus. Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pione…

In this episode Dr Cohen talks about why he started studying aging, his views on IGF-1 and his theory of why we age. Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitochondria-derived peptides and their possible therapeutic benefits for diabetes, Alzheimer's and other …

In this episode Dr Katz talk about how the quality of our food has changed in the past and how the concerns of the younger generation may impact it in the future. Dr Katz was an early proponent of preventative medicine and is the founder and former president of the Yale-Griffin Prevention Research Center. As well as appearing on ABC News and Good M…

@michaelsalzle

In this episode Dr Katz talks the company has formed and the tool that it has created with the aim of providing a quick and easy way to measure your diet quality and find steps to improve it. Dr Katz was an early proponent of preventative medicine and is the founder and former president of the Yale-Griffin Prevention Research Center. As well as app…

In this episode Dr Katz talks about his personal protocol for longevity and the reasons that he follows it. Dr Katz was an early proponent of preventative medicine and is the founder and former president of the Yale-Griffin Prevention Research Center. As well as appearing on ABC News and Good Morning America he has written 13 books including The Tr…

In this episode Dr Katz talks about whether, even with a healthy whole food diet, we should also include supplements and what those should be. Dr Katz was an early proponent of preventative medicine and is the founder and former president of the Yale-Griffin Prevention Research Center. As well as appearing on ABC News and Good Morning America he ha…

Dr Katz was an early proponent of preventative medicine and is the founder and former president of the Yale-Griffin Prevention Research Center. As well as appearing on ABC News and Good Morning America he has written 13 books including The Truth About Food and How to eat. He is the founder and CEO of Diet ID a company that makes a tool to help meas…

@michaelsalzle. Hot and cold protocols for improving performance, recovery, and overall health. Using glaborous skin to your advantage and the role of AVA‘s, the benefits of pre-exercise cooling, negative effects of cold exposure on exercise performance and adaptation, and heat exposure/heat shock proteins for improving performance and our health.…

In this episode Dr Katz talks a specific study comparing a Mediterranean to a keto diet and also discusses diet study design and why so many are pre-decided. We also talk about calorie restriction and intermittent fasting. Dr Katz was an early proponent of preventative medicine and is the founder and former president of the Yale-Griffin Prevention …

In this episode Dr Katz talks about his path to preventative medicine and how important it is. We then get into the number one modifiable cause of chronic diseases which is diet. Dr Katz was an early proponent of preventative medicine and is the founder and former president of the Yale-Griffin Prevention Research Center. As well as appearing on ABC…

In this episode Professor Furman shares his personal protocol to stay healthy and have low inflammation and talks about where the longevity industry is going and where he thinks it should put its focus. Dr. David Furman is the Director of the Stanford 1000 Immunomes Project, Chief of the Center for AI and Data Science of Aging at the Buck Institute…

Edifice Health aim not to only measure inflammatory age but to also to provide supplements and suggest actions to improve it. In this episode we talk about how these will be determined and some of the future direction. We also talk about the anti-inflammatory nature of caffeine. Dr. David Furman is the Director of the Stanford 1000 Immunomes Projec…