Parhaat Px Pulse Podcastit (2024)

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S5 Ep9: An HIV Vaccine: Looking into the future with Nina Russell 15:55

18d ago15:55

15:55

It’s considered one of the most important and most difficult scientific enterprises in the history of modern medicine—the hunt for an HIV vaccine. It has led to vast knowledge of HIV and the immune system, and to breakthrough technology. But developing an effective HIV vaccine is still out of reach, while HIV incidence remains high in hard-hit plac…

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S5 Ep8: PxPulse: The Advocacy Chronicles with APHA’s Yvette Raphael 12:41

2M ago12:41

12:41

Our debut episode of the Advocacy Chronicles features Yvette Raphael, the Executive Director of Advocacy for Prevention of HIV and AIDS (APHA) in South Africa, and a leader in the development of The Choice Manifesto, supported from start to finish by CASPR. As co-chair of the African Women Prevention Community Accountability Board (AWPCAB), Yvette …

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S5 Ep7: Decolonizing Global Health: Dr. Madhukar Pai and COMPASS Africa Tell Us Why and How 32:14

2M ago32:14

32:14

In this episode of PxPulse, we talk about why and how the decisions that shape global health must be made by those facing the greatest risks. As the world evaluates the pandemic response and debates on decolonizing global health gain momentum, equity in global health has never been more urgent. This conversation features global health leader and cr…

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S5 Ep6: Inclusion of Pregnant and Lactating People in HIV Research: What you need to know 34:31

7M ago34:31

34:31

People who are pregnant or lactating (PLP) have historically been excluded from research because of concerns for the developing fetus. But this has led to a dearth of data on new interventions against health threats for this population. In the case of HIV, pregnancy raises the risk of acquiring HIV by up to three times, but providers often do not h…

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S5 Ep5: PEPFAR at 20: Keeping the promise 23:16

9M ago23:16

23:16

2023 is a big year for PEPFAR. PEPFAR’s considered one of the greatest US foreign policy and global development achievements of the century; the program has saved upwards of 25 million lives since it launched in 2003. But PEPFAR is marking its 20th anniversary while fighting for its future. Its authorization expires Sept. 30th. Until a couple of mo…

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S5 Ep4: Evolving Strategies for an HIV Vaccine: One researcher explains where the field is going and why? 21:25

1y ago21:25

21:25

With several large HIV vaccine trials in the last few years finding no efficacy, the field is in transition. There are diverse ideas in vaccine research, but there's no clear concept that's ready to test in a late-phase trial or move toward product development currently. Researchers are back to testing new ideas in early-phase research. In this epi…

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S5 Ep3: LGBTQIA+ Advocacy in Uganda: Facing down fear and fighting for justice 24:19

1y ago24:19

24:19

In March 2023, the Ugandan Parliament moved forward broad-reaching legislation to further criminalize LGBTQIA+ people. The bill would make it a crime to even identify as lesbian, gay, bisexual, transgender or queer, with sentences up to life imprisonment. It gives authorities wide powers to crackdown on anyone who does not report on same-sex couple…

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S5 Ep2: PPPR Advocacy 101: Find out what it means for you. 19:05

1y ago19:05

19:05

Over the coming months, global leaders will make key decisions about several initiatives to prepare for the next pandemic. What they commit to and how much they will spend, and how well these plans incorporate equity as a principle across all of these initiatives, is in question. Deadlines for civil society to influence these decisions are coming u…

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S5 Ep1: The Shape of Pandemic Preparedness is Being Decided. Now is the Time for Collective Action. 15:15

1y ago15:15

15:15

Health leaders and advocates around the world are in the midst of creating a new architecture to deal with pandemics. This means new structures, systems and financing for pandemic prevention, preparedness and response — PPPR, for short. A lot is being discussed, and a lot more is riding on the decisions. Chris Collins, the CEO and President at Frie…

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S4 Ep7: New Products are Needed and a New Paradigm is Essential: A new era in prevention? 28:11

1+ y ago28:11

28:11

With all the talk about new HIV prevention products such as the dapivirine vaginal ring or injectable cabotegravir for PrEP, what’s little understood is how to match proven products with programs, policies and the political will that's needed to get these products to the people who need them. PEPFAR Ambassador Dr. John Nkengasong shares his plan fo…

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S4 Ep6: Research Fundamentals: An HIV Vaccine — What’s the challenge and what’s the science? 12:23

2y ago12:23

12:23

In this episode, AVAC’s Jeanne Baron and co-host immunologist Katharine Kripke of AVENIR Health explore why developing a vaccine for HIV is different from other viruses. Two vaccine researchers, Caltech’s Pamela Bjorkman and IAVI’s Vincent Kioi, lend their expertise. Learn how HIV has evolved like no other virus that exists today to escape detectio…

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S4 Ep5: What Matters Right Now For The Rollout Of The Ring And Injectable PrEP? 25:33

2y ago25:33

25:33

Linda-Gail Bekker from South Africa’s Desmond Tutu Health Foundation and Lillian Mworeko from the International Community of Women Living with HIV East Africa (ICWEA) join host Jeanne Baron and AVAC’s Executive Director Mitchell Warren to discuss innovative models for scale-up and delivery. Taking the right steps now could mean HIV prevention optio…

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S4 Ep4: Research Fundamentals: What is an endpoint? 9:01

2+ y ago9:01

9:01

Endpoints are a crucial component in every clinical trial but they are not always well understood, and putting them in context is essential for effective advocacy. This next installment of the Px Pulse series, Research Fundamentals, which explores key scientific concepts, lays out what endpoints are and why they matter.…

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S4 Ep3: Special Interview with AVAC’s Micheal Ighodaro, featured in HBO's Legends of the Underground 14:36

3y ago14:36

14:36

The latest episode of Px Pulse goes behind the scenes of the new HBO movie, The Legend of the Underground. The film documents the lives of AVACer Micheal Ighodaro and other LGBTQ Nigerians as they confront enormous risks to ‘live out loud’.Kirjoittanut Px Pulse

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S4 Ep2: A New Look at PEPFAR 20:12

3y ago20:12

20:12

The latest episode of Px Pulse takes a deep dive into PEPFAR, The President’s Emergency Plan for AIDS Relief. AVAC’s former Director of Strategy and Content, Emily Bass, has just published To End a Plague: America’s fight to end AIDS in Africa which documents its pioneering successes and its challenges.…

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S4 Ep1: The AMP Trials- bNAbs for HIV Prevention 23:57

3y ago23:57

23:57

Findings from two trials on antibody-mediated prevention, the AMP Trials, have been generating discussion since the beginning of the year. The results are complex, and the implications for HIV prevention research are unfolding.Kirjoittanut Px Pulse

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S1 Ep24: CAB-LA is a Highly Effective HIV Prevention Option; Now what? 23:09

3+ y ago23:09

23:09

Early results from trials testing cabotegravir as a long-acting injectable PrEP show it was safe and highly effective against HIV. Listen to learn what must come next for CAB-LA to advance HIV prevention alongside oral PrEP and the Dapivirine Vaginal Ring?Kirjoittanut Px Pulse

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S1 Ep23: A Leap Forward For the Dapivirine Vaginal Ring, the Next Steps Are Critical 37:13

3+ y ago37:13

37:13

After decades of research and advocacy, the ring is now one step closer to becoming available as a discreet, woman-initiated HIV prevention option.Kirjoittanut Px Pulse

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S1 Ep22: Research Fundamentals: What is partial protection? 11:42

4y ago11:42

11:42

Whether it’s condoms, a flu shot, oral PrEP or the dapivirine vaginal ring, proven products fall short of 100 percent protection against disease, and there’s a lot to know about how and why an intervention may offer imperfect but still useful protection. This episode is part of a new series on Px Pulse, Research Fundamentals…

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21: The Intersections of HIV and COVID-19 in Real-Time 17:32

4y ago17:32

17:32

In this episode of Px Pulse, hear unique perspectives on how COVID-19 and HIV are shaping one another. Mark Feinberg, CEO of IAVI, and Helen Rees, Executive Director of the Wits Reproductive Health and HIV Institute (Wits RHI), speak to COVID-19 vaccine development. Sinead Delany-Moretlwe, Director of Research at Wits RHI, Vincent Basajja of the Ug…

1
S1 Ep20: HVTN 702 and the Quest for Vaccine 21:12

4y ago21:12

21:12

Kirjoittanut Px Pulse

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S1 Ep19: 2020 Global Targets for Prevention Will Not Be Met: Now What? 14:37

4+ y ago14:37

14:37

With unmet UNAIDS “Fast-Track” targets for ending the epidemic now a reality, the field faces the sobering truth. We’ve been striving towards the 90-90-90 treatment targets without an equal commitment to primary prevention targets. In this episode of Px Pulse, AVAC’s Emily Bass, lead author of our repot Now What?, talks about AVAC’s blueprint for c…

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S1 Ep18: Now what with F/TAF for PrEP? A call for action in 2020 13:55

4+ y ago13:55

13:55

A look at what’s different and what’s the same between F/TDF (Truvada) and F/TAF (Descovy), what’s driving innovation in the proposed trial design, why it's so essential for advocates to engage and more.Kirjoittanut Px Pulse

1
S1 Ep17: Human-Centered Design and Prevention in the Real World 23:50

4+ y ago23:50

23:50

Breaking the Cycle of Transmission, a human-centered design (HCD) project, is shedding new light on how to bring HIV prevention to adolescent girls and young women.Kirjoittanut Px Pulse

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S1 Ep16: The ECHO Trial Results: Time to Act 16:22

5y ago16:22

16:22

The results of the ECHO trial are out. A much-anticipated study has found no difference in risk among three highly effective contraceptives. But the study also found high HIV infection rates among the women in the study in East and Southern Africa- almost 4 percent. What do the researchers, advocates and the WHO think of the results?…

1
S1 Ep15: ECHO Trial: Preparing for Action 23:42

5y ago23:42

23:42

The ECHO trial (Evidence for Contraceptive options in HIV Outcomes) looked at three highly effective contraceptive methods to determine if one carried a higher risk of acquiring HIV compared to the others. Mixed data from previous observational studies had raised questions about one particularly popular method, known as DMPA-IM. The results of ECHO…

1
S1 Ep14: The Science of Choice: The future of HIV prevention research 24:03

5y ago24:03

24:03

In this episode of Px Pulse, hear DAIDS leader Carl Dieffenbach and colleague Director Sheryl Zwerski address the position of non-systemic strategies of prevention at the January AIDS Research Advisory Committee meeting, where funding priorities were presented. (Non-systemic strategies such as topical microbicides do not provide protection througho…

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S1 Ep13: Community Engagement and The Next Generation of Trial Design 15:43

5+ y ago15:43

15:43

How will future clinical trials need to be designed as HIV prevention evolves…and how can community engagement become stronger along with it? Check out this episode to hear three fierce voices tackle the questions: Morenike Giwa-Onaiwu of the Houston HIV Cross-Network Community Advisory Board, Stacey Hannah- AVAC’s Director of Research Engagement &…

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S1 Ep12: The Prevention Crisis and How to End it: AVAC Report 2018 and R4P 19:08

5+ y ago19:08

19:08

The bi-ennial conference on HIV research for prevention, or R4P, is “the” place where HIV prevention science, policy & advocacy come together to share insights and identify what’s next for the field. In this episode of Px Pulse, Ntando Yola, a veteran advocate and part of the Coalition to Accelerate and Support Prevention Research (CASPR) shares hi…

1
S1 Ep11: Combination Prevention and AIDS 2018 20:59

6y ago20:59

20:59

In this episode of Px Pulse we take a look at one issue that was center-stage at the recent AIDS 2018 conference in Amsterdam: Preventing new HIV infections. Hear Brad Jones of Weill Cornell Medical College pose a basic question about T cells and what his research could teach us about the immune system. Advocate Dorothy Okatch of the NGO Young 1ove…

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S1 Ep10: Cure Research and Analytic Treatment Interruption 25:47

6y ago25:47

25:47

Researchers and advocates debate the rationale, risks and ethics of interrupting treatment as part of cure research. This is known as analytic treatment interruption or ATI. AVAC spoke with advocate Udom Likhitwonnawut about when and why treatment interruption might make sense. Two cure researchers—Dr. Steven Deeks and Dr. Dave Margolis—share their…

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S1 Ep9: HIV Vaccine Science: From Research to Advocacy 27:14

6y ago27:14

27:14

AVAC’s May episode of Px Pulse features four experts steeped in HIV vaccine research. Together they help set expectations for where the field is now and where it is going. For more information about HIV vaccine science go to www.avac.org/px-pulse!Kirjoittanut Px Pulse

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S1 Ep8: From the Trenches: Advocates Share their Prevention Priorities. 16:38

6y ago16:38

16:38

In this episode we bring you two different conversations, each throwing a spotlight on different aspects of HIV prevention advocacy today. AVAC’s Manju Chatani-Gada talks with seasoned and new advocates who attended AVAC’s African Advocacy Partners’ Forum in Johannesburg. You’ll hear how the forum brought key issues into focus and how these advocat…

1
S1 Ep7: What's Next for Dapivirine Ring 30:43

6y ago30:43

30:43

In March, initial results from the two open-label trials of the dapivirine vaginal ring (HOPE and DREAM) showed that adherence and efficacy improved over the earlier Phase III trials. Learn more about all these trials at https://www.avac.org/podcast/dapivirine-ring. Meanwhile, The ring is also advancing along the pathway to licensure. If approved, …

1
S1 Ep6: Three Perspectives, Two Trials and One Big Goal 16:43

6+ y ago16:43

16:43

With more efficacy trials underway today than ever before in HIV prevention research, this episode of Px Pulse zooms in on two that have most recently launched: HPTN 084 and HVTN 705. Veteran Malawian advocate Maureen Luba, Zimbabwe-based bioethicist Paul Ndebele, and leading scientist Dan Barouch each take up the subject of these trials and share …

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S1 Ep5: 2018 and HIV Prevention: AVAC's Take 8:03

6+ y ago8:03

8:03

In this episode hear about recently published findings from a study out of Rakai, Uganda confirm that scaling up a combination of existing interventions, such as voluntary medical male circumcision and antiretroviral therapy provides protection from HIV at the population-level. How do we apply these findings at the global level? How should advocate…

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S1 Ep4: What's the state of the field? AVAC report 2017: Mixed Messages and How to Untangle Them 14:36

6+ y ago14:36

14:36

AVAC has just published its annual report on the state of the field. AVAC Report 2017: Mixed Messages and How to Untangle Them. It's a must read for anyone tracking the progress of HIV prevention around the world. In this month’s episode of Px Pulse, AVAC’s Director of Strategy and Content Emily Bass shares major highlights from the report and call…

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S1 Ep3: Standard of Care in the Era of PrEP 18:09

6+ y ago18:09

18:09

Every research trial of a new HIV prevention option offers a package of services to protect participants from HIV. This standard of care is essential to the design of an ethical trial.Kirjoittanut Px Pulse

1
S1 Ep2: Testing Long-Acting PrEP, Easier Said Than Done 11:57

6+ y ago11:57

11:57

Leading researcher Dr. Deborah Donnell tells us why the HIV Prevention Trials Network (HPTN) changed the design of one of two trials testing long-acting cabotegravir, as an injectable PrEP. Deb Donnell is an expert statistician, one of the great minds behind trial design and one of the best teachers we know.…

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S1 Ep1: Trial Trial Again, Getting Research Right for Adolescents 11:28

6+ y ago11:28

11:28

Both research and advocacy for HIV prevention are intensifying their focus on young people. Bringing interventions that work for this population holds unique challenges. AVAC’s Manju Chatani-Gada explores how and why prevention research must reach the next generation. You'll hear from two young, South African women at a trial consultation, Sinazo P…

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