Exploring all things genetics. Dr Patrick Short, University of Cambridge alumnus and CEO of Sano Genetics, analyses the science, interviews the experts, and discusses the latest findings and breakthroughs in genetic research. To find out more about Sano Genetics and its mission to accelerate the future of precision medicine visit: www.sanogenetics.com
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Welcome to the The Buff, a Bolton Wanderers podcast from The Bolton News. Join chief football writer Marc Iles for a light-hearted look at the latest headlines on and off the pitch as well as rumours, reaction, and some big-name guests.
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A Leicester Tigers fans’ podcast. Unofficial and probably ill-informed, Mike and Elliott bring you a weekly dose of match reviews, previews, general chat and wildly optimistic predictions. Follow on Twitter at: @rollingmaulpod or email us at therollingmaul@outlook.com
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The Exeter Chiefs Podcast is a weekly show for fans of the Chiefs, we chat to the boys & chew the fat about anything else happening in the world and of course we talk Rugby.
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The Leicester Tigers Women's Fancast Chatting about all things to do with Leicester Tigers women's team. Hosted by Jess Bunyard and Jacob Bassford
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There's trouble at th' mill... What next for Bolton Wanderers?
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1:14:19
Back to back defeats have raised frustration among Bolton Wanderers fans - and swelled the contents of our postbag too! The Buff boys Marc and Henry bring you bang up to date on a busy week at the Whites, with big questions being asked of Ian Evatt and his side over the international break. As ever, we bring all the headlines from The Bolton News, …
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EP 150: Cracking the biological code of aging with Martin Borch Jensen, Co-Founder and Chief Scientific Officer at Gordian Biotechnology
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Martin 01:35 How a particularly large Indian meal resulted in a book about intermittent fasting and the biology of ageing 05:10 The biological mechanisms behind intermittent fasting, and whether it’s been established to extend life expectancy in humans. 10:13 What we know (and what we don’t) about…
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Cozza - Martin Corry Interview, Nottingham (H) Review, Scarlets (H) Preview
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1:19:19
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Mike and Elliott have the privilege of being joined by Tigers legend Martin Corry to chat about long lunches, glory years and young talent, whilst separately casting an eye over what the first pre-season game against Nottingham promised for the season ahead and looking at what we want to see next up against the Scarlets.…
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The Last Word - Barrow 2 Bolton Wanderers 3
17:16
17:16
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WELCOME back to the Last Word – a mini podcast from The Bolton News with all the reaction from Tuesday night's 3-2 win at Barrow in the Bristol Street Motors Trophy. We hear from Ian Evatt and Aaron Collins in the Wanderers camp and get the verdict of Buff co-host Henry Hewitt on the opening group game. Marc Iles talks you through all the night's a…
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The Last Word - Bolton Wanderers 0 Exeter City 2
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22:14
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22:14
WELCOME back to the Last Word – a mini podcast from The Bolton News with all the reaction from Saturday's 2-0 home defeat to Exeter City. We hear from Ian Evatt and Ricardo Santos and talk about a deeply dissatisfying afternoon at the Toughsheet Stadium, which leaves the Whites 18th in the table after four games.…
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EP 149: Sequencing 33 million samples to support the UK’s COVID-19 response with Tony Cox, CEO of UK Biocentre
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Tony 02:00 What Tony was expecting going into the role of CEO at UK Biocentre, and how the COVID-19 pandemic changed his plans 03:38 Receiving a phone call from the UK government in March 2020 asking the UK Biocentre to stop all of its projects and focus on sequencing COVID-19 samples 05:12 The UK…
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The Buff presents: The one before transfer deadline day
1:14:48
1:14:48
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1:14:48
THE Buff Podcast is back, it’s early, and packed with news and gossip before deadline day! We decided to release this week’s episode a little early, just in case our attentions are diverted elsewhere on Friday. Ian Evatt has admitted there has been some interest in his top players and that the remaining days could yet be busier than planned, so we …
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Who Gives a Shirt? - Premiership Preview, Nottingham (H) Preview
1:14:35
1:14:35
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Mike and Elliott behold a magnificent new European jersey, get excited about Fijian international Ben Volavola popping up and make idiots of themselves by predicting how the rest of the Premiership will fare this year. Do not use our guesswork as gambling advice. Even more hopeless than our league predictions are our stabs at what the Tigers XV wil…
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The Last Word - Shrewsbury Town 0-2 Bolton Wanderers
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18:12
WELCOME back to the Last Word – a mini podcast from The Bolton News with all the reaction from tonight’s 2-0 win at Shrewsbury Town in the Carabao Cup second round. We hear from Ian Evatt, Jordi Osei-Tutu plus the analysis of The Buff podcast’s Marc Iles and Henry Hewitt as the Whites progressed to the next stage with goals from Jordi Ossei-Tutu an…
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Nobbly necks, transfer tales and back into The Valley we go!
1:17:04
1:17:04
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1:17:04
The Buff Podcast rides again, and as it's getting closer to transfer deadline day we decided to dedicate a large chunk of this week's show to the possible outs (and ins) at Bolton Wanderers. Marc Iles and Henry Hewitt review the week's headlines from The Bolton News and look ahead to this weekend's visit to Charlton Athletic, a venue that has produ…
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EP 148: Advancing veteran health through the Million Veteran Program with Dr. Mike Gaziano, professor of medicine at Harvard Medical School
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0:00 Intro 2:00 Mike’s career prior to the Million Veteran Program (MVP), how Mike got to work on MVP, and important milestones in the project's evolution 8:30 Future goals for the Million Veteran Program in expanding and diversifying the research cohort 11:00 The roles of various omics in advancing the project's development 14:30 The most meaningf…
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The Cheika Era Begins
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1:10:16
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Mike and Elliott herald in a new season with some cautious optimism (having learned their lesson from indulging in the full-blown variety). We look at what Cheika will do differently to McKellar, what we can look forward to seeing on the field and list our predictions for the upcoming season. Plus, Mike drops a bombshell...…
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The Last Word - Bolton Wanderers 0 Wrexham 0
18:07
18:07
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WELCOME back to the Last Word – a mini podcast from The Bolton News with all the reaction from today’s 0-0 draw with Wrexham in League One. We hear from Ian Evatt, George Johnston and Phil Parkinson on a tense 90 minutes plus the analysis of The Buff podcast’s Marc Iles and Henry Hewitt.Kirjoittanut The Bolton News
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Wrexham, Parkinson and 25,000 reasons to prove us all wrong...
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1:22:07
WELCOME to another episode of The Buff Podcast. Pull up a chair, stick the kettle on, we have got plenty to talk about in the busy world of Bolton Wanderers. Ian Evatt's side kicked off their season with a win at Leyton Orient and then backed it up by beating Mansfield Town in the Carabao Cup on penalties. Neither performance was flawless - but can…
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EP 147: From research to delivering precision medicine in the clinic with Scott Weiss, Professor of Medicine at Harvard University
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Scott 01:55 Scott’s career highlights to date, ranging from epidemiology to the genetics of asthma and chronic obstructive pulmonary disease (COPD) 04:56 How and why Scott decided to transition into genetics 06:30 The advances in our understanding of the genetics of asthma and COPD over the past 2…
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The Last Word - Bolton Wanderers 1-1 Mansfield Town (Bolton win 5-4 on pens)
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WELCOME back to The Last Word - and this episode centres of Bolton Wanderers' dramatic 5-4 penalty shootout victory against Mansfield Town in the Carabao Cup first round. Hear from Ian Evatt and from goalkeeper hero Luke Southwood, plus The Buff Podcast's resident experts Marc Iles and Henry Hewitt. If you have any feedback on The Last Word, please…
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The Last Word - Leyton Orient 1 Bolton Wanderers 2
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21:57
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IT'S the very first Last Word of the new season and Wanderers are off to a winning start at Leyton Orient. Catch up with everything that happened at Brisbane Road with Marc Iles, along with analysis from co-host Henry Hewitt, plus the latest from Ian Evatt and goalkeeper Nathan Baxter.Kirjoittanut The Bolton News
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The season is here... Is it OK to be optimistic now?
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1:18:37
THE new season is upon us - and we plan to podcast about it! Wanderers have been busy in the transfer market on the eve of the new League One campaign and their opening game at Leyton Orient. Jay Matete, Jordi Osei-Tutu have already signed up and John McAtee was on the cusp as we recorded this episode on Friday. We talk about what each deal means a…
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EP 146: The biology of aging with Austin Argentieri, Research Fellow at Harvard Medical School, Affiliate Member of the Broad Institute, and Research Fellow at Massachusetts General Hospital
43:05
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Austin 01:42 What is aging and how should we think about it? 03:50 Discussion of Austin’s recent breakthrough paper on aging, including the questions he set out to answer, and the outcomes of the research 06:32 How Austin’s work focuses on using large-scale population proteomics data to create acc…
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The Buff's Official League One Predictions Podcast
1:33:52
1:33:52
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1:33:52
IT'S that time of year again where Henry Hewitt channels his inner Paul the Octopus and Marc rummages round for his crystal balls in an attempt to make sense of what is coming up in League One this season. The Buff is back once again for episode 239, and the usual look through all the headlines at Bolton Wanderers, the transfer news and gossip, and…
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EP 145: Navigating rare disease drug development regulations with Daniel O’Connor
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39:12
0:00 Intro to The Genetics Podcast 01:00 Welcome to Daniel 02:04 Defining rare disease in the age of personalized medicine 04:57 Key touchpoints with the Medicines and Healthcare products Regulatory Agency (MHRA) when developing a new medicine 09:27 Improvements over the course of Daniel’s career when it comes to incentivizing and making the path t…
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The Buff presents: Time's a ticking for Wanderers
1:10:56
1:10:56
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1:10:56
The new season is drawing closer and Wanderers still have plenty to do in the transfer market. Ian Evatt has revealed some serious bids have been made but, at time of recording, there were no deals on the immediate horizon. Should Bolton fans be concerned? Is the squad looking any stronger than it was last season? Marc Iles and Henry Hewitt chew th…
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EP 144: Research Roundup with Dr. Veera: breakthroughs in developmental disorders, Parkinson's, SLE, and Alzheimer's
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56:48
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56:48
0:00 Introduction 1:40 A recurrent de novo mutation in a noncoding region of a small nucleolar RNA gene that has been identified as one of the most common causes of neurodevelopmental disorders This pathogenic variant escaped notice for years because it was not located in a protein coding region of the genome It now shows potential as a target for …
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Can someone open the transfer window?... It's getting hot!
1:18:02
1:18:02
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1:18:02
WANDERERS have made four signings this summer but the transfer rumour mill has been in full force this week, with some big names tipped to be the fifth man through the door. Marc Iles and Henry Hewitt are back to bring you all the big stories from Bolton Wanderers this week, as covered by The Bolton News. We have seen moves for exciting attacker Ka…
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EP 143: Harnessing human data in drug development with Jakob Steinfeldt, Co-Founder and Chief Scientific Officer at Pheiron
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Jakob and background on Pheiron 02:14 What made Jakob decide to start Pheiron, what the company does, and how his scientific background inspired him to found a start-up 5:24 Jakob’s excitement and inspiration around the power and potential of machine learning 07:07 Cardiology and heart failure as …
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Transfer gossip, Luke Southwood and Steve Eyre talks BWFC
1:07:44
1:07:44
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1:07:44
WE kick off a sixth season of The Buff Podcast with two special guests, a raft of transfer gossip and a discussion about whether Lilt should ever have been rebranded as grapefruit Fanta. Marc Iles and Henry Hewitt are back once again to guide you through all the Bolton Wanderers stories from The Bolton News this week, including a few transfer tales…
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EP 142: From genome to bedside: How genetics is transforming modern medical practice with Dr. Andrea Gropman
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0:00 Introduction 1:40 Andrea’s background and how she got into the field of genetics, neuroimaging, and metabolic disorders 4:00 Insights into Andrea’s clinical practice, including the diverse families and patients she serves and her approach to clinical decision-making 6:30 How genetics and genomics have changed the diagnostic journey in the last…
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The Buff presents: Killing stories in the name of...
1:04:15
1:04:15
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1:04:15
WELCOME back to another episode of The Buff Podcast, the show that takes you through the whole week's headlines at Bolton Wanderers, and reveals some behind-the-scenes stories as we go. The players and staff might have been sunning themselves in Portugal but it has been another eventful week at the Toughsheet Stadium - and we bring you exclusive co…
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EP 141: Bringing genomics to the clinic with Lori Orlando, Associate Prof at Duke University
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43:24
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0:00 Intro to The Genetics Podcast 01:00 Welcome to Lori Orlando 03:00 Lori’s career: From mathematical modelling to genetics and family history 05:11 The study that revealed 20% of the general population is at a higher risk of disease than average and needs preventative care 07:36 The first five diseases that Lori started analysing through informa…
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Finding Rico and moving on at Bolton Wanderers
1:17:30
1:17:30
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1:17:30
After a few quiet weeks at Bolton Wanderers, The Buff finds itself positively overflowing with news in an episode some people are calling "one of the best they have done this week". Marc Iles and Henry Hewitt once again disassemble the week's headlines in The Bolton News - including some stories that haven't even hit the printers yet - as the club …
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EP 140: The future of Electronic Health Records and data analysis with Ben Goldacre
52:51
52:51
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52:51
0:00 Intro to The Genetics Podcast 1:00 Welcome to Ben Goldacre 02:22 Ben’s open data projects at the Bennett Institute and the challenges they aim to tackle 04:03 Using Electronic Health Records (EHR) to help the National Health Service improve care 06:18 The importance of software development within healthcare data and how to manage salary scales…
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The Buff presents: Bolton Wanderers' Fixturemas or Fixturepalooza?
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31:26
WE'RE back with a special update episode bringing you reaction to the Bolton Wanderers' fixture list in podcast form! Marc Iles and Henry Hewitt guide you through the homes and aways of 2024/25, where the points might come from, and where the toughest runs lie. We'll be back with the full podcast on Friday morning, complete with all the usual headl…
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EMERGENCY POD - Dan McKellar Leaves!
45:20
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45:20
Mike and Elliott fire up the dreaded "emergency podcast" klaxon and awake from their peacefully chaotic summer slumbers to react to the stunning news that Dan McKellar has left the Tigers "by mutual consent". We look at whether or not it's the right call, the bizarre timing of the announcement and who is likely to step into the breach. Plus we chat…
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New signing, top friendly and a tribute to 'our Tommy'
1:16:43
1:16:43
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1:16:43
FORGET the Euros - there's plenty to talk about at Bolton Wanderers. No, really, there is... Marc Iles and Henry Hewitt are back to bring you a podcast episode packed with news, gossip and headlines to keep you right up to date with everything going on at the Toughsheet Stadium. It has been a sad week at Bolton, with the passing of club legend Tomm…
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EP 139: Rare disease breakthroughs using tRNA with Michelle Werner, CEO of Alltrna and CEO-Partner of Flagship Pioneering
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44:42
0:00 Intro to The Genetics Podcast. 01:00 Welcome to Michelle. 02:00 Sstop codon diseases and how are they characterised 03:45 Diseases caused by premature stop codons in haploinsufficient genes. 04:35 The role of transfer RNA technology in finding solutions for premature stop codon diseases. 06:16 How Alltrna is engineering tRNAs which can bind to…
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The End of Season Review
1:46:45
1:46:45
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1:46:45
With Jess recovered from jet lag and Jacob recovered from a post-exam Otley Run, the two JBs are back for one final episode of Season 1 to do an End of Season Review. We briefly review the last game of the season against Exeter Chiefs before announcing our coveted, no-expense-spared, highly prized LTW Fancast End of Season Awards. We then debate on…
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What's that noise? Is it the transfer window opening?
1:26:32
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1:26:32
WELCOME to another episode of The Buff Podcast, where the absence of news at Bolton Wanderers just gives us something else to talk about! Marc Iles and Henry Hewitt are back again for a deep dive into the week’s headlines in The Bolton News and an extensive chat about everything happening around the club (which isn’t a lot, as it turns out) as the …
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The Buff presents: Sharon's speech and the BWFC rebuilding job
1:23:39
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1:23:39
IT might be pre-season but here at The Buff don't believe in putting our feet up. Spread over a lung-bursting 82 minutes, we bring you bang up to date with all the latest news at Bolton Wanderers and the headlines from The Bolton News, as told by the people who wrote the stories. Sharon Brittan has given us all something to talk about this week, pu…
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EP 138: Personalised medicine using microbiome models with Dr. Almut Heinken
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40:22
0:00 Introduction 1:45 Almut’s research experience, including two recent publications on genome-scale metabolic reconstruction human microorganisms Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine APOLLO: A genome-scale metabolic reconstruction resource of 247,092 diverse human microbes spanning multiple…
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The Buff: Honestly, what's next for Bolton Wanderers?
1:13:15
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1:13:15
If we based this week's podcast on the number of newsy headlines to come out of Bolton Wanderers, it would be about 30 seconds long. But thankfully, our magnificent listeners have emailed in with another collection of thoughts and ruminations which have given us plenty to talk about two weeks on from 'that' Wembley play off final defeat. Where are …
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EP 137: Mavis Machirori on promoting equity, diversity, and social justice in genomics research
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0:00 Intro 1:30 Mavis’ career arc, from starting as a midwife to researching medical innovation and technology with an emphasis on advocacy and equity 7:00 Systemic issues that are easily overlooked in medical research and advancements Webinar: Participant Diversity: Increasing the Impact of Biomedical Research Webinar 10:00 Addressing Eurocentrici…
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The End of Season Review
1:38:07
1:38:07
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1:38:07
Mike and Elliott are joined by Radio Leicester's Adam Whitty and the LTW Fancast's Jacob Bassford to wrap up a complicated and ultimately disappointing season for the Tigers. What went wrong? Can it be fixed? And by how many points will we top the league next year?! Warning: may involve deluded optimism.…
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You're MacQueen [said in your best John Snow voice] - Sale Sharks (H) Review, Exeter Chiefs (A) Preview
1:22:22
1:22:22
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1:22:22
Jacob is once again joined by the wonderful Alex Bugg to process a sad 24 hours for the club, in which the team yet again failed to turn up at home followed by the news on Sunday morning that Vicky MacQueen will be departing the club at the end of the season. After giving a cathartic review of the game, and paying tribute to Vicky as well as recent…
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The Sad Buff Podcast: If you didn't laugh, you'd cry...
1:15:15
1:15:15
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1:15:15
LEAVING aside the usual jokes and banter, we've got something serious to talk about on The Buff this week. Wanderers' poor show at Wembley means another year in League One and some big decisions to be made by everyone at the Toughsheet Stadium. Fans are understandably annoyed that a big chance for promotion has been blown, and believe you me, they …
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EP 136: Developments in ring chromosome 20 research and advocacy with Allison Watson
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40:57
0:00 Introduction 2:00 Allison’s personal journey to researching epilepsy and ring chromosome 20 syndrome 4:00 Biggest challenges families face with ring chromosome 20 syndrome 11:00 Incidence and prevalence of r(20) syndrome, and how we can improve data reliability 21:00 Applying next generation sequencing to r(20) syndrome gene research 29:00 Eng…
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Blueprint? - Chiefs (H) Review
1:12:55
1:12:55
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1:12:55
Mike and Elliott enjoy a meaningless-yet-important win in the final game of the season for Tigers, one that hopefully points at brighter days to enjoy come September. We pay a tearful tribute to some departing legends and assess what the performance says about the way the team wants to play.Kirjoittanut Mike and Elliott
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A Clifton Suspension Bridge Too Far - Bristol Bears (A) Review, Sale Sharks (H) Preview with guest co-host Alex Bugg
1:10:53
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1:10:53
With Jess dialling in with voice notes from New Zealand reacting to a sensational win by Canada over the Black Ferns and positives from Tigers' defeat to the Bears, Jacob is pulled out of his deadline slumber by being joined by the wonderful Alex Bugg to co-host. We go over some of the positives from the Bristol game, especially getting that try-sc…
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One more game: The Buff's Wembley special part two
1:06:21
1:06:21
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1:06:21
WANDERERS are going to Wembley in the League One play-off final and, as ever, The Buff has got it completely covered. This is part two of a double podcast helping this week, containing the all-important predictions for the big game. Marc Iles and Henry Hewitt reconvene after part one for some overtime, chatting to the Oxford Mail's Liam Rice about …
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One more game: The Buff's Wembley special part one
1:15:44
1:15:44
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1:15:44
WANDERERS are going to Wembley in the League One play-off final and, as ever, The Buff has got it completely covered. This is part one of a double podcast helping this week, looking at a week of headlines in The Bolton News and setting the scene for the big game against Oxford United. Marc Iles and Henry Hewitt discuss Sharon Brittan's appearance i…
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EP 135: Integration of newborn sequencing programs into healthcare systems with Dr. Ingrid Holm
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41:16
0:00 Introduction 1:30 Ingrid’s initial interests in genetics, paediatrics, and newborn screening 2:45 How the original BabySeq project, a pioneering newborn sequencing program got started, how it’s going, and the launch of BabySeq2 8:45 Lessons from BabySeq1 and goals for BabySeq2 10:30 Potential societal and long-term considerations for those inv…
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