AoPcasts is a fascinating series of podcasts bringing cutting edge medical research to new audiences. Produced by the Association of Physicians (AoP) and hosted by science broadcaster Vivienne Parry, the series will explore some of the major themes debated at the annual AoP meeting. The first AoPcast brings together Rino Rappuoli, Chief Scientist of the vaccines division of GSK and Fellow both of the Royal Society and the US National Academy of Sciences, and Ellie Barnes, Professor of Experimental Medicine at the University of Oxford, globally celebrated for her work on hepatitis vaccines.