Parhaat Physiology Podcastit (2024)

1
Road to Valencia- 2 weeks to go 47:15

1d ago47:15

47:15

2 weeks to go, the hay is in the barn, the work is banked. Dan & Owain talk through the last "big" week of training before Valencia marathon. Dan travels up north for a wedding, but before that runs one last big treadmill session, with some final shoe testing. Dan's session planning is also discussed in a listener question. If you have any question…

1
Chronic Pain & The Brain 51:22

16d ago51:22

51:22

I am joined by functional neurologist Martin Fenn to discuss how the brain effects our perceptions of pain and ways in which we can maximise brain health in order to reduce pain.Kirjoittanut Chris Knott

1
"Got Guts" The Micro Version: Electromechanical Coupling of the In-Vivo Pylorus 13:02

20d ago13:02

13:02

Join coauthors Sam Simmonds, Ashton Matthee, and Timothy R. Angeli-Gordon as they delve into their recently published research, "Electromechanical Coupling and Anatomy of the In Vivo Gastroduodenal Junction." In this episode, they explore cutting-edge techniques like electrical mapping, impedance planimetry, and histological analysis to investigate…

1
Guidelines for Mechanistic Modeling and Analysis in Cardiovascular Research 30:02

23d ago30:02

30:02

In our latest episode, Dr. Jeff Saucerman (University of Virginia) interviews authors Dr. Naomi Chesler (University of California, Irvine) and Dr. Mitchel Colebank (University of South Carolina) about their new Guidelines in Cardiovascular Research article on incorporating mechanistic modeling into the analysis of experimental and clinical data to …

1
Road to Valencia- 3 weeks to go 57:37

10d ago57:37

57:37

A big week in the books for Dan, with two sessions and a long run. Dan & Owain break down the sessions, and take a deep dive into some shoe testing numbers as Dan decides on his shoes for the big dance in Valencia. The Physiology of Endurance Running podcast is now proudly sponsored by SOAR. SOAR produce high quality running clothing, designed to f…

1
Heat, the poor man's altitude? 56:18

15d ago56:18

56:18

On today's episode, Dan & Owain take an initial dive into the physiology heat exposure.They first discuss the physiological benefits and drawbacks to altitude, and how this can lead many to using heat as a means to increase haemoglobin mass.They then discuss different forms of heat exposure, including baths and sauna, and the physiology behind unde…

1
Road to Valencia- 4 weeks to go 45:22

17d ago45:22

45:22

Dan & Owain are back to discuss Dan's training with 4 weeks to go until the Valencia Marathon! Dan's week began on a high note, before coming down with a cold. Dan logged a fast long run beforehand, which is broken down, along with a few listener questions! The Physiology of Endurance Running podcast is now proudly sponsored by SOAR. SOAR produce h…

1
Road to Valencia- 5 weeks to go 50:19

24d ago50:19

50:19

A big week in the books for Dan, and a big episode to break it down! Dan & Owain discuss the sessions, as well as Dan's carbs & bicarb use during the sessions - and his thinking for using them during the marathon itself. A longer episode than normal, but a lot of information to cover! The Physiology of Endurance Running podcast is now proudly spons…

1
Strength & Conditioning for Endurance Runners 51:53

29d ago51:53

51:53

Dan & Owain are back to discuss strength and conditionining training. A growing body of research has focussed on S&C training and its impact on endurance training. Dan & Owain talk through some of the myths and possible benefits of S&C, and how to apply these to your own training.If you're interested in reading more about S&C, Richard Blagrove's bo…

1
Road to Valencia- 6 weeks to go 35:44

1M ago35:44

35:44

Dan & Owain are back again to dissect Dan's training - but begin with an exciting announcement about the podcast! With 6 weeks to go until Valencia marathon, Dan returns to a fairly normal training week! Using lab data to guide his return to sessions, they go through Dan's aborted session, followed by a quality session later in the week. They also …

1
Road to Valencia- 7 weeks to go 26:32

1M ago26:32

26:32

In this episode, we review Dan's week following his PB at Cardiff Half Marathon. Initially, a positive start, with a quick recovery from the race. We then discuss Dan's strength training regime that he has introduced as a "marginal gain" in this Valencia block. Unfortunately, Dan then caught one of the many viruses going around which led to three d…

1
"Got Guts" The Micro Version: Effect of amniotic fluid on the esophageal epithelium 7:50

1M ago7:50

7:50

Join coauthors Mark Rochman and Marc E. Rothenberg as they explore their recently published paper, "Amniotic Fluid Modifies Esophageal Epithelium Differentiation and Inflammatory Responses." In this engaging episode, they discuss how the interaction between amniotic fluid and the esophageal epithelium during pregnancy impacts epithelial differentia…

1
"Got Guts" The Micro Version: The Effects of Simulated Gastroesophageal Reflux on Infant Pig Oropharyngeal Feeding Physiology 7:20

1M ago7:20

7:20

Join coauthor Chloe Edmonds in this insightful episode as she delves into her recently published paper, "The Effects of Simulated Gastroesophageal Reflux on Infant Pig Oropharyngeal Feeding Physiology." Chloe explores how simulating gastroesophageal reflux in an infant pig model reveals significant alterations in pharyngeal swallowing dynamics. Dis…

1
Behind the Bench Episode 15 with Hannah Cizauskas 24:27

1M ago24:27

24:27

In this episode of Behind the Bench, we are talking with Hannah Cizauskas about her first, first-author article published in AJP-Heart and Circ. Born and raised in Detroit, Hannah moved to Chicago for what she thought would be just one rotation outside of the cancer genetics field. This led Hannah to work on a project related to atrial fibrillation…

1
Road to Valencia- 8 weeks to go 38:57

1M ago38:57

38:57

In this new mini-series, we will share a week-by-week account of Dan's preparations for Valencia marathon where he is targeting the European Road Running Championships qualifying time of 2:12:30. As this is a podcast about physiology, the emphasis will be on how Dan uses his own data, and findings from the scientific literature, to optimise his tra…

1
Durability - the fourth dimension of endurance physiology? 50:50

2M ago50:50

50:50

After giving their excuses for recording a week later than planned, Dan & Owain delve into Durability. As they discuss, durability is a growing area of research and particularly impacts marathon (and ultra) performance. But how do you measure it, and how do you improve it? A new mini-series is announced to close the show...https://forms.gle/XGmxsR6…

1
"Got Guts" The Micro Version: Autoimmune liver disease and hormonal responses 5:56

2M ago5:56

5:56

In this episode, coauthors Anne-Sofie H. Jensen and Nicolai J. Wewer Albrechtsen discuss the recently published research titled "Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease." The authors reveal that patients with autoimmune liver disease, even in the absence of overt diab…

1
The Physiology of the Marathon 1:01:41

2M ago1:01:41

1:01:41

In today's in-person episode, Dan and Owain break down the physiological components of marathon running. There's more to the marathon (and other distances) than just having a big VO2max! Thresholds, economy, and durability all interact with each other, and as you'll hear, there's more than one way to run a marathon from a physiological perspective.…

1
Runx1 Drives Cardiomyocyte Cell Cycle Activation 8:47

2M ago8:47

8:47

In our latest episode, Executive Editor Kara Hansell Keehan interviews lead author Dr. Michaela Patterson and first author Kaelin Akins (both at the Medical College of Wisconsin) along with expert Dr. Ana Vujic (University of Cambridge) about the new study by Akins et al. Given that the heart has limited regenerative potential, repairing damage to …

1
"Got Guts" The Micro Version: Inhibitory neurotransmission in the internal anal sphincter 8:43

3M ago8:43

8:43

Coauthor Caroline A. Cobine dives into the fascinating world of internal anal sphincter biology in the latest episode of "Gut Guts." The research uncovers direct and indirect neural pathways that modulate intracellular calcium activity in interstitial cells of Cajal, shedding light on their role in smooth muscle cell function. Article Citation: Mod…

1
How to pace your next marathon 1:04:16

3M ago1:04:16

1:04:16

Building on a very popular Twitter thread (https://x.com/Dan_Nash94/status/1797744471565574604),Dan & Owain discuss marathon pacing. First, an overview of some of the physiology that you'll be contending with during a marathon - especially if you go out too fast! Dan & Owain then discuss the pacing plan Dan has utilised in recent marathons, and how…

1
"Got Guts" The Micro Version: Mechanical Stress-induced Connective Tissue Growth Factor and Intestinal Fibrosis 8:25

3M ago8:25

8:25

In this episode of "Gut Guts" coauthor Xuan-Zheng Shi discusses new research on intestinal fibrosis in Crohn’s-like colitis. The study found that mechanical stress causes a protein called CTGF to increase, leading to fibrosis. In a rat model, easing the mechanical stress reduced connective tissue growth factor (CTGF) and lessened fibrosis. This sug…

1
Cooling headbands, Bicarb, Beetroot and Caffeine: What is worth spending your money on? 1:04:52

3M ago1:04:52

1:04:52

In this episode, Dan and Owain explore the research on the supplements and accessories that have recently been hitting the headlines. They share what the research has to say on their effectiveness including, who may benefit the most, the risk-reward ratio, and advice on implementation strategies. Dan finishes the podcast with a plug of both the Spo…

1
"Got Guts" The Micro Version: Characterization of Rat Gastric Slow Wave Activity 8:29

3M ago8:29

8:29

Tune in to our latest podcast episode where Peng Du, Omkar N. Athavale, and Madeleine R. Di Natale dive into the fascinating world of gastric slow-wave conduction. They discuss their recent article titled "Mapping the rat gastric slow-wave conduction pathway: bridging in vitro and in vivo methods, revealing a loosely coupled region in the distal st…

1
Is threshold training dead? 46:24

3M ago46:24

46:24

Is threshold training old news? Should we all be following the "American Method"? Dan & Owain talk through the mens 1500m Olympic final; how the race played out, what training is best to run a championship 1500m, will we see a shift of training methods in the next 4 years. What did you think of the 1500m final, and the rest of the Olympic events? D…

1
Acute Intranasal Insulin Increases MSNA in Healthy Adults 14:25

4M ago14:25

14:25

What is the impact of central insulin on muscle sympathetic nerve activity (MSNA) and vascular conductance in the absence of peripheral insulin delivery? Listen as Associate Editor Dr. Jason Carter (Baylor University) interviews authors Neil McMillan and Dr. Jackie Limberg (both at University of Missouri), along with expert Dr. Manda Keller-Ross (U…

1
Human Induced Pluripotent Stem Cell Derived Cardiomyocyte Electrophysiology and Experimental Reproducibility 14:20

4M ago14:20

14:20

Sometimes experimental results are serendipitous. Listen as Associate Editor Dr. Crystal Ripplinger (University of California, Davis) talks with authors Dr. Nikki Posnack and Devon Guerrelli (both at Children’s National Hospital and The George Washington University School of Engineering and Applied Science), along with expert Dr. Silvia Marchiano (…

1
Serum Estradiol and Cardiovascular Health Among Transgender and Nonbinary Adults Using Gender Affirming Estrogen Therapy 36:32

4M ago36:32

36:32

Hormone modulation therapy is a growing area of research in cardiovascular science related to a number of factors, such as menopause and andropause, cancers in hormone-producing organs, as well as gender-affirming hormone therapy. So how do scientists and clinicians measure, monitor, and balance applications of hormone therapy? In our latest podcas…

1
Fuelling for Endurance (A Chat w/ Effortless Swimming) 56:53

4M ago56:53

56:53

Nick recently was invited on the Effortless Swimming podcast to chat about our new testing equipment in the lab and discuss the practical implications of being able to use data to start dialling in further your fuelling needs when racing and training. To learn more about Effortless Swimming CLICK HERE For more free resources about improving enduran…

1
The Physiology of the Warm Up 44:55

4M ago44:55

44:55

In this episode Dan & Owain discuss the physiology of the warm up. For many runners, a warm up features some jogging and possibly a few strides. But the warm up of a professional runner differs significantly, due to some interesting research into what is often referred to as "priming". Dan & Owain discuss some of the history of the research, the ph…

1
Fuel Better, Race Better: Closing the Gap on Race-Day Nutrition 23:09

5M ago23:09

23:09

As you may have heard, we have some new lab testing equipment that has expanded our capabilities to go much deeper into your physiology. In this episode, we discuss the new metrics we can assess including Fat vs Carbohydrate utilisation and how we can pair that with an InBody composition analysis to better estimate and predict your race-day nutriti…

1
Easy running- why bother? 1:02:27

5M ago1:02:27

1:02:27

Welcome back! Dan finally feels like he has the time to relaunch the pod and is joined by new co-host, Owain Zerilli.In this episode, we delve into all things "easy running". We started with defining what easy running is from a physiology perspective, before going into describing what benefits we can (and can't) expect from training in "zone 2". We…

1
"Got Guts" The Micro Version: Implicating the Cholecystokinin B Receptor in Liver Stem Cell Oncogenesis 4:39

5M ago4:39

4:39

In this episode of "Got Guts" The Micro Version, Jill P. Smith highlights the recently published research titled "Implicating the cholecystokinin B receptor in liver stem cell oncogenesis." This investigation identified a novel pathway involving the activation of hepatic stem cells and liver oncogenesis. Receptor blockade or genetic disruption of t…

1
"Got Guts" The Micro Version: Corticotropin-Releasing Hormone Effects on Gastric Function 6:26

6M ago6:26

6:26

In this podcast, I-Hsuan Huang highlights the recently published paper titled "Effects of corticotropin-releasing hormone on gastric electrical activity and sensorimotor function in healthy volunteers: a double-blinded crossover study." The aim of this research was to investigate the effects of peripheral corticotropin-releasing hormone infusion on…

1
IL-33 Supplementation Improves RUPP Pathophysiology 25:28

6M ago25:28

25:28

While decreased IL-33 signaling has been associated with preeclampsia, the mechanisms linking this signaling pathway to disease pathophysiology are not well understood. In this episode, Associate Editor Dr. Amanda LeBlanc (University of Louisville) interviews author Dr. Denise Cornelius (University of Mississippi Medical Center) and expert Dr. Stel…

1
Scoliosis Management & Practice Development 47:36

6M ago47:36

47:36

I am joined by world leading Scoliosis specialist Ed Paget to discuss his methodology when it comes to treating back pain. *** Ed takes me through his origins story and how he was one of the first practitioners to pioneer Osteopathy in Canada. He explains how he built his practice and what foundations enabled him to grow. *** Ed also talks me throu…

1
"Got Guts" The Micro Version: Effects of L. Casei-Fermented Milk on Mice with DSS Colitis 7:07

6M ago7:07

7:07

Coauthors Mélanie G. Gareau and Maria L. Marco delve into the findings of their latest research titled "Milk and Lacticaseibacillus paracasei BL23 effects on intestinal responses in a murine model of colitis." This study marked the first exploration into sex-dependent responses to probiotic Lacticaseibacillus paracasei and milk, as well as the pote…

1
"Got Guts" The Micro Version: Characterize Mouse Glutamatergic Myenteric Neurons 6:22

6M ago6:22

6:22

In this episode, Jia Liu and Bin Feng highlight the recently published research titled "Morphological, molecular, and functional characterization of mouse glutamatergic myenteric neurons." In this research, the authors reveal that VGLUT2-positive enteric neurons (EN), although constituting a small fraction of total EN, are homogeneously expressed i…

1
The Self Development Series: Overcoming Mental Blocks 15:18

7M ago15:18

15:18

In the third instalment of the Self Development series I discuss mental blocks and what we can do to overcome them. *** I go through questions you can ask yourself to help you overcome whatever obstacles you’ve been facing. This is an interactive podcast where you’ll need to annotate your thoughts after each question.…

1
Mitochondrial Isolation in Aged Hearts 29:40

7M ago29:40

29:40

In this episode, Associate Editor Dr. Jonathan Kirk (Loyola University Chicago) interviews author Dr. Ed Lesnefsky (Richmond Department of Veterans Affairs Medical Center and Virginia Commonwealth University) and expert Dr. Chi Fung Lee (Oklahoma Medical Research Foundation) about the new Methods and Resources article by Chen et al. published in ou…

1
Guidelines on Use of Sex and Gender in Cardiovascular Research 17:23

7M ago17:23

17:23

In our latest episode, Consulting Editor Dr. Kristine DeLeon-Pennell (Medical University of South Carolina) interviews fellow co-authors Dr. Charlotte Usselman (McGill University), Dr. Judy Regensteiner (University of Colorado Anschutz Medical Campus), Dr. Kerrie Moreau (University of Colorado Anschutz Medical Campus), Dr. Austin Robinson (Indiana …

1
Debunking Dietary Fads 59:05

8M ago59:05

59:05

Steve and I discuss current dietary fads such as blood glucose monitoring, fasting and Keto diets. We explore which ones are the most effective, how valid they are and how to apply them correctly.Kirjoittanut Chris Knott

1
Behind the Bench Episode 14 1:18:58

8M ago1:18:58

1:18:58

After a yearlong hiatus, Behind the Bench is back, listeners! In this episode, we welcome back our B2B co-hosts Dr. Charlotte Usselman and Dr. Tommy Martin, who get the story behind the story from the one and only Dr. DeWayne Townsend, corresponding author of the recently published study by Stevens et al. Trust me, you are going to love listening t…

1
Left Ventricular Remodeling in Twin Pregnancy 18:05

9M ago18:05

18:05

In our latest episode, Associate Editor Dr. Amanda LeBlanc (University of Louisville) interviews author Prof. Pietro Modesti (University of Florence) and expert Dr. Alexandre da Silva (University of Mississippi Medical Center) about the new study by Pellegrino et al. that investigated the pattern of intraventricular hemodynamic forces associated wi…

1
”Got Guts” The Micro Version: Gastric Neuromuscular Transmission 5:29

9M ago5:29

5:29

In this episode of the Got Guts podcast series Madeleine R. Di Natale of the University of Melbourne discusses the recently published manuscript titled "Characterization of neuromuscular transmission and projections of muscle motor neurons in the rat stomach." This study provides a detailed mapping of nerve transmission to the circular muscle of th…

1
Training Clients With Osteoarthritis 38:04

9M ago38:04

38:04

Episode #222 - An Introduction to Osteoarthritis *** Recording this one was a real privilege. I’d like to introduce you to a lady by the name of Debra Bakowska. Debra is a Doctor of Osteopathy and had a Masters in Physiotherapy. She was my main tutor during my Osteopathy degree and I owe a lot of my concepts and treatment methods to her. *** To say…

1
Reducing Thrombotic Risks in Video Gamers 43:05

9M ago43:05

43:05

Ready Player One? In our latest episode, Dr. Keith Brunt (Dalhousie University) interviews lead author Dr. Joanne DiFrancisco-Donoghue (New York Institute of Technology) and expert Dr. Saurabh Thosar (Oregon Health and Science University Hospital) about a new article published in the AJP-Heart and Circ Call for Papers on Exercise, Physical Activity…

1
”Got Guts” The Micro Version: Gene expression and microbiome composition in EsoCaSR-/-mice 7:28

9M ago7:28

7:28

In this episode of the Got Guts Podcast series, Solange M. Abdulnour-Nakhoul of Tulane University, discusses the recently published manuscript titled "Alterations in gene expression and microbiome composition upon calcium sensing receptor deletion in the mouse esophagus." In this research Abdulnour-Nakhoul et al. highlight why calcium sensing recep…

1
Self Development Series Part 2: Vision 25:21

9M ago25:21

25:21

In the second instalment of the Self Development Podcast Series I discuss why it’s so important to have a vision of where you want to go and who you want to be. *** This episode includes an interactive element where you can do a “self assessment” on how clear you are with your vision and how you can work on it on a daily basis…

1
"Got Guts" Special Episode: The GI and Liver Section at the 2024 American Physiology Summit 11:26

9M ago11:26

11:26

Listen as Editor in Chief of AJPGI and Liver Physiology, Mark Frey and the Chair of the Gastrointestinal & Liver Section, Pradeep Dudeja discuss what they are looking forward at the 2024 American Physiology Summit, April 4-7th. Registration Deadline for American Physiology Summit is March 11, 2024. Click here for more info on the American Journal o…

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