Episode 23 - Help I found a paraprotein | MGUS + The Spectrum of Plasma Cell Dyscrasias

Bloody Minded

Ordered something you shouldn’t have and accidentally found a paraprotein again? Shame on you, but now you have to do something with it. Maybe you were genuinely suspicious for myeloma. If incidentally discovered lab findings are leaving you smouldering, this is the episode for you!
Join Nick, Cale and Bashar as they chat about the spectrum of plasma cell dyscrasias, and cover the precursor conditions MGUS and Smouldering Myeloma.
Timestamps
2:53 - What is a paraprotein?
5:56 - The heavy chain component
9:40 - The spectrum of plasma cell disorders
10:12 - MGUS
11:33 - How common is MGUS?
15:24 - You've found a paraprotein - what next?
17:38 - IMWG MGUS Criteria
19:47 - Mayo Score for Risk Stratification
22:25 - Serum free light chain ratio
24:25 - Bence Jones proteins
26:21 - Smouldering myeloma
27:30 - IMWG Smouldering myeloma criteria
29:16 - Risk of progression to MM

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Luvut

1. Episode 23 - Help I found a paraprotein | MGUS + The Spectrum of Plasma Cell Dyscrasias (00:00:00)

2. What is a paraprotein? (00:02:53)

3. The heavy chain component (00:05:56)

4. The spectrum of plasma cell disorders (00:09:40)

5. MGUS (00:10:12)

6. How common is MGUS? (00:11:33)

7. You've found a paraprotein - what next? (00:15:24)

8. IMWG MGUS Criteria (00:17:38)

9. Mayo Score for Risk Stratification (00:19:47)

10. Serum free light chain ratio (00:22:25)

11. Bence Jones proteins (00:24:25)

12. Smouldering myeloma (00:26:21)

13. IMWG Smouldering myeloma criteria (00:27:30)

14. Risk of progression to MM (00:29:16)