Lethal Buttock Injection (And Other Toxicities of Illegal Cosmetic Body Fillers)

The Poison Lab

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3y ago 55:42

MP3•Jakson koti

Music in this episode from pixabay.com

Intro
- Case report of hemolysis after sodium deoxycholate injection
History
Epidemiology
Common injection practices
Toxicity
- Infection
  - Self explanatory
- Filler embolism
  - Review 1, Review 2, Review 3
    - Filler lodges in pulmonary vasculature->clotting, bleeding, inflammation
    - 95% occur within 72 hours
    - Primarily respiratory symptoms (cough/hypoxemia)
    - Chest x ray ground glass opacity
    - Treat with supportive care (oxygen all the way through ECMO) +/- steroids
- Filler Blindness
  - CRAO from body filler
  - No effective treatment (exception, can use hyaluronidase if filler is hyaluronic acid)
- Granuloma
  - Inflammatory nodules from prolonged filler exposure
    - May occur months to year after injection
    - Illegal cosmetic= frequently lipogranuloma due to oil being present in many illegal cosmetic
- Granulomatous hypercalcemia
  - Excess calcitriol production from ganuloma causes hyperCA
  - Can be extremely delayed (up to 28 years)
  - Recurrence up to 45%
  - Treat with standard therapies (fluid, bisphosphonate) + steroids and/or ketoconazole to turn down granuloma CYP27B1 calcitriol production
Case from the show
- Some details changed for educational purposes

56 jaksoa

Lethal Buttock Injection (And Other Toxicities of Illegal Cosmetic Body Fillers)

The Poison Lab

17 subscribers

published 3y ago

Jaa

MP3•Jakson koti

Music in this episode from pixabay.com

Intro
- Case report of hemolysis after sodium deoxycholate injection
History
Epidemiology
Common injection practices
Toxicity
- Infection
  - Self explanatory
- Filler embolism
  - Review 1, Review 2, Review 3
    - Filler lodges in pulmonary vasculature->clotting, bleeding, inflammation
    - 95% occur within 72 hours
    - Primarily respiratory symptoms (cough/hypoxemia)
    - Chest x ray ground glass opacity
    - Treat with supportive care (oxygen all the way through ECMO) +/- steroids
- Filler Blindness
  - CRAO from body filler
  - No effective treatment (exception, can use hyaluronidase if filler is hyaluronic acid)
- Granuloma
  - Inflammatory nodules from prolonged filler exposure
    - May occur months to year after injection
    - Illegal cosmetic= frequently lipogranuloma due to oil being present in many illegal cosmetic
- Granulomatous hypercalcemia
  - Excess calcitriol production from ganuloma causes hyperCA
  - Can be extremely delayed (up to 28 years)
  - Recurrence up to 45%
  - Treat with standard therapies (fluid, bisphosphonate) + steroids and/or ketoconazole to turn down granuloma CYP27B1 calcitriol production
Case from the show
- Some details changed for educational purposes

56 jaksoa

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Lethal Buttock Injection (And Other Toxicities of Illegal Cosmetic Body Fillers)