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Sisällön tarjoaa Science Changing Life and Scripps Research. Science Changing Life and Scripps Research tai sen podcast-alustan kumppani lataa ja toimittaa kaiken podcast-sisällön, mukaan lukien jaksot, grafiikat ja podcast-kuvaukset. Jos uskot jonkun käyttävän tekijänoikeudella suojattua teostasi ilman lupaasi, voit seurata tässä https://fi.player.fm/legal kuvattua prosessia.
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Squid Game is back, and so is Player 456. In the gripping Season 2 premiere, Player 456 returns with a vengeance, leading a covert manhunt for the Recruiter. Hosts Phil Yu and Kiera Please dive into Gi-hun’s transformation from victim to vigilante, the Recruiter’s twisted philosophy on fairness, and the dark experiments that continue to haunt the Squid Game. Plus, we touch on the new characters, the enduring trauma of old ones, and Phil and Kiera go head-to-head in a game of Ddakjji. Finally, our resident mortician, Lauren Bowser is back to drop more truth bombs on all things death. SPOILER ALERT! Make sure you watch Squid Game Season 2 Episode 1 before listening on. Let the new games begin! IG - @SquidGameNetflix X (f.k.a. Twitter) - @SquidGame Check out more from Phil Yu @angryasianman , Kiera Please @kieraplease and Lauren Bowser @thebitchinmortician on IG Listen to more from Netflix Podcasts . Squid Game: The Official Podcast is produced by Netflix and The Mash-Up Americans.…
Episode 27 – Overcoming arthritis: Scripps Research Magazine
Manage episode 394318131 series 1908208
Sisällön tarjoaa Science Changing Life and Scripps Research. Science Changing Life and Scripps Research tai sen podcast-alustan kumppani lataa ja toimittaa kaiken podcast-sisällön, mukaan lukien jaksot, grafiikat ja podcast-kuvaukset. Jos uskot jonkun käyttävän tekijänoikeudella suojattua teostasi ilman lupaasi, voit seurata tässä https://fi.player.fm/legal kuvattua prosessia.
In the second of this series on healthy aging, we reveal how Scripps Research scientists are developing interventions to remove stiff, achy joints from the aging equation. This article is taken from the Summer 2021 of our award-winning Scripps Research Magazine. Show notes: Explore the Scripps Research Magazine https://magazine.scripps.edu/
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Manage episode 394318131 series 1908208
Sisällön tarjoaa Science Changing Life and Scripps Research. Science Changing Life and Scripps Research tai sen podcast-alustan kumppani lataa ja toimittaa kaiken podcast-sisällön, mukaan lukien jaksot, grafiikat ja podcast-kuvaukset. Jos uskot jonkun käyttävän tekijänoikeudella suojattua teostasi ilman lupaasi, voit seurata tässä https://fi.player.fm/legal kuvattua prosessia.
In the second of this series on healthy aging, we reveal how Scripps Research scientists are developing interventions to remove stiff, achy joints from the aging equation. This article is taken from the Summer 2021 of our award-winning Scripps Research Magazine. Show notes: Explore the Scripps Research Magazine https://magazine.scripps.edu/
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×Long COVID affects millions of people worldwide, yet many questions about the condition remain unanswered. In this episode of Science Changing Life, Julia Moore Vogel, PhD, shares what it’s like to study—and live with—long COVID. As the senior director of the All of Us Research Program, Julia discusses how her experience has fueled innovative research to improve symptom management and health equity for patients with the condition. Listen in to learn how Julia transforms personal challenges into professional breakthroughs. Twitter: https://x.com/julialmv LinkedIn: https://www.linkedin.com/in/juliamoorevogel All of Us Research Program: https://www.joinallofus.org/ Scripps Research Magazine: magazine.scripps.edu/…
In the second part of our conversation with Dr. Eric Topol, we explore how examining the past is necessary to ensure we’re more prepared for our future. From universal vaccines and advanced antiviral therapies to cutting-edge digital tools like wearable biosensors and genomic surveillance, Dr. Topol shares actionable insights on harnessing technology and data to revolutionize pandemic preparedness. Listen in as we discuss the path to a safer, healthier future. // Episode transcript: https://www.scripps.edu/_files/images/2024_images/topol-pandemic-prep-transcript.pdf Twitter: https://twitter.com/EricTopol LinkedIn: https://www.linkedin.com/in/eric-topol-md-b83a7317/ Ground Truths podcast: erictopol.substack.com Scripps Research Magazine: magazine.scripps.edu/…
Artificial intelligence is revolutionizing what we once thought impossible. But how can we distinguish genuine breakthroughs from mere hype? In this episode of Science Changing Life, we welcome Eric Topol, MD—renowned physician, scientist, and author. As executive vice president at Scripps Research and founder of the Scripps Research Translational Institute, Dr. Topol shares his thoughts on how AI is transforming science and medicine today and offers a glimpse into what the future may hold. His advice to listeners? 'Be open to change.' Twitter: https://twitter.com/EricTopol LinkedIn: https://www.linkedin.com/in/eric-topol-md-b83a7317/ Ground Truths podcast: erictopol.substack.com Scripps Research Magazine: magazine.scripps.edu/…
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Thanks to revolutionary technologies like CRISPR, we’re now living in an age where it’s becoming possible to rewrite the very building blocks of life itself—our DNA. We sit down with Scripps Research Fellow and CRISPR expert Shannon Miller, PhD, to discover how these gene editing technologies are poised to reverse a range of diseases. Listen in as we explore Shannon’s unique journey into science—beginning not with a single eureka moment, but instead with a passion for creativity and discovery. Twitter: https://twitter.com/_shannonmmiller Miller lab: https://www.millerlabresearch.com/team Scripps Research Magazine: https://magazine.scripps.edu/…
Four years after the onset of the COVID-19 pandemic, another virus threatens to reach pandemic potential: the H5N1 bird flu. We sit down with Arnab Chatterjee, vice president of medicinal chemistry at Calibr-Skaggs, who explains the need to invest in the best science to make sure we’re more prepared than we were for the SARS-CoV-2 outbreak. Chatterjee breaks down how likely it is for H5N1 to become transmitted between humans, and the steps we can take now to better protect ourselves in the future. LinkedIn: linkedin.com/in/arnab-chatterjee-b024661/ Scripps Research Magazine: magazine.scripps.edu/…
Galileo’s telescope revolutionized our modern understanding of the universe. Assistant neuroscience professor Xin Jin, PhD, wants to do just that—except for the brain. By building new tools that enable her and other neuroscientists to peer into the inner workings of the mind, Jin is uncovering the cells, genes and other complex drivers behind neurological diseases. Listen in as we explore the galaxy of the brain. Twitter: https://x.com/xinjin Jin lab: https://www.jin.scripps.edu/ Scripps Research Magazine: magazine.scripps.edu/…
More than 90% of drugs fail to make it from the lab bench to approval. How, then, has a physician-scientist like Hugh Rosen found so much success in developing medicines? Rosen, who’s the chair of molecular and cellular biology at Scripps Research, co-invented the drugs ozanimod (approved for multiple sclerosis and ulcerative colitis) and navacaprant (in Phase 3 trials for major depressive disorder). In this episode of Science Changing Life, listen in as Rosen unveils the success stories behind these groundbreaking treatments—shedding light on the challenges and triumphs shaping modern medicine. Rosen Lab: https://www.scripps.edu/rosen/index.html Scripps Research Magazine: magazine.scripps.edu/…
Donna Blackmond never thought her career would lead to solving how life first formed on the prebiotic Earth. But as she points out in this episode of Science Changing Life, does any scientist start out knowing where their research will take them? Blackmond, who is a professor and the John C. Martin Endowed Chair in Chemistry at Scripps Research, shares how her wide-ranging background across chemistry and chemical engineering is helping answer some of today’s biggest questions in science and medicine. Episode transcript: https://www.scripps.edu/_files/images/2024_images/donna-blackmond-podcast-episode-45-transcript.pdf Blackmond Lab: https://www.scripps.edu/blackmond/ Blackmond’s recent PNAS and Nature papers: https://www.scripps.edu/news-and-events/press-room/2024/20240228-blackmond-molecules.html Scripps Research centennial: 100.scripps.edu/ Scripps Research Magazine: magazine.scripps.edu/…
Dr. Jay Pandit is a director of digital medicine at the Scripps Research Translational Institute and an assistant professor in the Department of Molecular Medicine at Scripps Research, where he combines medicine and technology to improve patients’ clinical outcomes. Listen in as we explore how biosensors and wearable technologies are enabling users to take control of their own health data and usher in a new era of personalized medicine. Episode transcript: https://www.scripps.edu/_files/images/2024_images/jay-pandit-transcript.pdf X: https://twitter.com/JayPandit LinkedIn: www.linkedin.com/in/jay-pandit-9489008 Scripps Research centennial: https://100.scripps.edu/ Scripps Research Magazine: https://magazine.scripps.edu/…
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Ahmed Badran is an assistant professor of chemistry at Scripps Research, where his lab harnesses synthetic biology to address some of biggest global problems. Listen in as we discuss reengineering plant enzymes to capture carbon, plastic-eating bacteria and new classes of antibiotics that spare our gut microbiome. Episode transcript: https://www.scripps.edu/_files/images/2023_images/ahmed-badran-transcript.pdf Badran lab website https://badranlab.com/ Twitter @AhmedHBadran Scripps Research Magazine https://magazine.scripps.edu/…
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Professor Mia Huang is based in the Department of Molecular Medicine at Scripps Research, where her lab explores how vital sugar molecules in the body orchestrate complex biological events. Listen in as we discuss deciphering cancer cell signals to develop new therapies, engineering red blood cells for transfusions and how to become a master of strategy. Episode transcript: https://www.scripps.edu/_files/images/2023_images/mia-huang-transcript.pdf Huang lab website https://www.huangresearch.com/ Q&A with Mia https://magazine.scripps.edu/profiles/2020/fall/science-with-a-view-understanding-how-natures-biomolecules-tick-with-mia-huang/ Twitter @HuangMia Scripps Research Magazine https://magazine.scripps.edu/…
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1 Episode 41 – Ram Krishnamurthy: Astrobiology, origins of life and the search for extraterrestrials 22:57
Professor Ram Krishnamurthy is based in the Department of Chemistry at Scripps Research, where his lab investigates the reactions that could have first given way to life on Earth. Listen as we discuss finding biological building blocks on meteorites, NASA’s search for life on other planets, and staying grounded with philosophy and meditation. Episode transcript https://www.scripps.edu/_files/images/2023_images/ram-krishnamurthy-transcript.pdf Ram’s faculty profile https://www.scripps.edu/faculty/krishnamurthy/ Astrobiology at NASA https://astrobiology.nasa.gov/news/new-nasa-research-consortium-to-tackle-lifes-origins/ Scripps Research Magazine https://magazine.scripps.edu/…
Professor Sumit Chanda is an infectious disease expert and immunologist, where he works both in the Department of Immunology and Microbiology and at Calibr, Scripps Research’s nonprofit drug discovery and development division. He has devoted his career to understanding how the immune system responds to numerous viruses, such as influenza, Dengue virus and SARS-CoV-2. Listen as we discuss everything from pandemic preparedness to drug discovery, as well as his unrelenting drive to uncover new treatment options—including for COVID-19. Episode transcript https://www.scripps.edu/_files/images/2023_images/sumit-chanda-transcript.pdf Infectious disease sleuth Sumit Chanda, PhD, joins Scripps Research and its Calibr drug discovery division https://www.scripps.edu/news-and-events/press-room/2021/20210915-chanda-calibr.html Center for Antiviral Medicines & Pandemic Preparedness https://www.campp.org/ Chanda lab website https://linktr.ee/thechandalab Twitter/Instagram @thechandalab…
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Professor Ali Torkamani is the Director of Genome Informatics at the Scripps Research Translational Institute, where his team mines population-level genetic data to make predictions about future disease risk. Listen in as we discuss smartphone apps that could help predict the risk of a heart attack, the addition of genetic data to biosensors of the future and the use of video games as an introduction to data science. Show notes: Episode transcript: coming soon…. MyGeneRank app https://mygenerank.scripps.edu/ Ali’s faculty profile https://www.scripps.edu/faculty/torkamani/ Twitter @ATorkamani Scripps Research Magazine https://magazine.scripps.edu/…
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1 Episode 38 – Danielle Grotjahn: What mitochondria tell us about disease, stress and cell death 33:23
Are the mitochondria truly the powerhouses of the cell? In this episode, assistant professor Danielle Grotjahn shares why she thinks “the stress sensors of the cell” may be a more appropriate name for this cellular organelle–and more. Dr. Grotjahn works in the Department of Integrative Structural and Computational Biology at Scripps Research, where her lab is answering how mitochondrial networks change shape in response to genetic, pharmacological or environmental stress. Listen as we talk about the links between mitochondrial dysfunction and disease, cell death, and the cutting-edge imaging technologies that are enabling Grotjahn and her team to peer into the mysteries of the mitochondria. Show notes: Episode transcript: https://www.scripps.edu/_files/images/2023_images/danielle-grotjahn-transcript.pdf Grotjahn lab website https://grotjahnlab.org/ Twitter @nani_grotjahn Scripps Research Magazine https://magazine.scripps.edu/…
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Dr. Stuti Jaiswal is an assistant professor of molecular medicine at Scripps Research and an internist at Scripps Clinic. Listen in as we discuss the health issues associated with insufficient sleep, the best time to go to bed and what the latest wearables can tell us about our sleep patterns. Show notes: Episode transcript: https://www.scripps.edu/_files/images/2023_images/stuti-jaiswal-transcript.pdf REFRESH sleep study at Scripps Research https://refresh.scripps.edu/ The Digital Trials Center current research https://digitaltrials.scripps.edu/about/ Scripps Research Magazine https://magazine.scripps.edu/…
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1 Episode 36 – Evert Njomen: Hacking our cellular recycling system to prevent the next deadly pathogen 18:07
Dr. Evert Njomen is a postdoctoral researcher in the lab of Professor Ben Cravatt, based in the Department of Chemistry. Listen as we talk about the autophagy process to cleanse cells, new ways of dealing with antibiotic resistance and cooking with homegrown herbs. Show notes: Episode transcript: https://www.scripps.edu/_files/images/2022_images/podcast-images/Evert-Njomen-transcript.pdf Evert awarded prestigious fellowship from the Howard Hughes Medical Institute https://www.scripps.edu/news-and-events/press-room/2021/20210304-njomen-howard-hughes-medical-institute-fellowship.html Cravatt lab website https://www.scripps.edu/cravatt/index.html Tweet @EvertNjomen Explore the Scripps Research Magazine https://magazine.scripps.edu/ Subscribe to receive our monthly e-newsletter https://signup.e2ma.net/signup/1879047/1890109/ @scrippsresearch on Twitter…
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Professor Andrew Su is based in the Department of Integrative Structural and Computational Biology, where his lab develops digital tools to draw conclusions from the vast streams of medical data generated each day. Listen to us discuss gaming as a way of being a scientist, the replacement of doctors with machine-learning and your Netflix watching history. Show notes: Episode transcript: https://www.scripps.edu/_files/images/2022_images/podcast-images/Andrew-Su-transcript.pdf Andrew’s TEDx talk: Building the knowledgebase of biology using citizen science https://www.youtube.com/watch?v=hT_pj1cB0Q8 Su lab website https://sulab.org/ Tweet: @andrewsu Citizen science initiatives: https://www.zooniverse.org/ https://fold.it/ https://stallcatchers.com/main Explore the Scripps Research Magazine https://magazine.scripps.edu/ Subscribe to receive our monthly e-newsletter https://signup.e2ma.net/signup/1879047/1890109/ @scrippsresearch on Twitter…
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Dr. Travis Young is the Vice President of Biologics at Calibr, the drug discovery and development division of Scripps Research. Travis and the team have created a new type of immunotherapy called “switchable” chimeric antigen receptor (CAR) T-cell therapy, which is already delivering precise and powerful therapies to patients with the most difficult to treat cancers. Listen as we talk about reengineering an individual’s immune T cells, promising clinical trials in leukemia and lymphoma patients, and using similar approaches to treat autoimmune diseases. Show notes: Episode transcript: https://www.scripps.edu/_files/images/2022_images/podcast-images/Travis-Young-transcript.pdf Travis and his colleagues discuss ongoing therapies being developed at Calibr during the Front Row lecture series https://www.youtube.com/watch?v=WRzQniqUlHo&t=2625s Preliminary results of switchable CAR-T cells in lymphoma patients https://www.scripps.edu/news-and-events/press-room/2021/20211208-calibr-announces-clinical-data-car-t-cells.html Tweet: @CARTCellTherapy Explore the Scripps Research Magazine https://magazine.scripps.edu/ Subscribe to receive our monthly e-newsletter https://signup.e2ma.net/signup/1879047/1890109/ @scrippsresearch on Twitter…
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1 Episode 33 – Frederick Barrett: Psychoactive compounds to treat depression, addiction & inflammation 22:21
Part three of our mini-series centered on brain health. Professor Frederick Barrett is based in the Department of Psychological & Brain Sciences at Johns Hopkins School of Medicine and Associate Director at the Center for Psychedelic and Consciousness Research. Fred and his colleagues investigate the therapeutic effects of psychoactive substances in intractable patient populations, including those with depression, opioid use disorder and cognitive impairments. Listen as we talk about the different types of hallucinogenic mushrooms, whether psychedelics could one day treat neurodegeneration and the remedial value of a bad “trip.” Show notes: Episode transcript: https://www.scripps.edu/_files/images/2022_images/podcast-images/Frederick-Barrett-transcript.pdf Fred’s TEDMED talk: The neuroscience of psychedelic drugs, music and nostalgia https://www.ted.com/talks/frederick_streeter_barrett_the_neuroscience_of_psychedelic_drugs_music_and_nostalgia?language=en Center for Psychedelics and Consciousness Research https://hopkinspsychedelic.org/barrett Tweet: @FredBarrettPhD Explore the Scripps Research Magazine https://magazine.scripps.edu/ Subscribe to receive our monthly e-newsletter https://signup.e2ma.net/signup/1879047/1890109/ @scrippsresearch on Twitter…
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The second part of our three-part mini-series on brain health. Professor Ryan Shenvi is based in the Department of Chemistry at Scripps Research, where his lab reconstructs useful molecules typically found in remote corners of the world. Listen as we talk about traditional remedies of indigenous cultures, formulating medicines from industrial waste and Charles Dickens’ drinking habits. Show notes: Episode transcript: https://www.scripps.edu/_files/images/2022_images/podcast-images/Ryan-Shenvi-transcript.pdf Shenvi finds a quick way to synthesize novel neuroactive compounds found in rainforest tree https://www.scripps.edu/news-and-events/press-room/2022/20220317-shenvi-neuroactive-compounds-in-rainforest-tree.html Q&A with Ryan https://magazine.scripps.edu/profiles/2022/online-exclusive/channeling-ethnomedicine-to-address-mental-health/ Shenvi lab website https://www.shenvilab.org/ Tweet: @Shenvi_Lab Explore the Scripps Research Magazine https://magazine.scripps.edu/ Subscribe to receive our monthly e-newsletter https://signup.e2ma.net/signup/1879047/1890109/ @scrippsresearch on Twitter…
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1 Episode 31 – Sandra Encalada: Linking traffic jams in the brain to neurodegenerative disease 30:57
We kick off the Summer 2022 podcast season with the first of a three-part mini-series dedicated to brain health. Professor Sandra Encalada is based in the Department of Molecular Medicine at Scripps Research, where her lab investigates the transport of cargo within brain cells and its role in health and disease. Listen as we talk about new therapeutic agents to stop and reverse neurodegeneration, environmental neurotoxins and when to listen to your gut feeling. Show notes: Episode transcript: https://www.scripps.edu/_files/images/2022_images/podcast-images/Sandra-Encalada-transcript.pdf Encalada illuminates how brain cells die in prion diseases https://www.scripps.edu/news-and-events/press-room/2021/20211222-encalada-brain-cells-prion-diseases.html Encalada lab website https://www.encalada.scripps.edu/ Tweet: @EncaladaLab Explore the Scripps Research Magazine https://magazine.scripps.edu/ Subscribe to receive our monthly e-newsletter https://signup.e2ma.net/signup/1879047/1890109/…
The fifth and final episode in our healthy aging series. We discover what happens inside the cell with age and how new chemical tools are leading us towards ways of repairing the damage and preserving our youth. This article is taken from the Summer 2021 of our award-winning Scripps Research Magazine. Show notes: Explore the Scripps Research Magazine https://magazine.scripps.edu/…
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The fourth segment of our series on healthy aging. We take a look at how breakthroughs in chemistry have enabled the rational design of therapies that can stop or slow complex diseases of the heart and nervous system. This article is taken from the Summer 2021 of our award-winning Scripps Research Magazine. Show notes: Explore the Scripps Research Magazine https://magazine.scripps.edu/…
We roll on with part 3 of our healthy aging series. We examine the role of our DNA blueprint in the risk of cardiovascular disease, as well as how understanding our personal genetic risk scores could help us avoid that deadly heart attack. This article is taken from the Summer 2021 of our award-winning Scripps Research Magazine. Show notes: Explore the Scripps Research Magazine https://magazine.scripps.edu/…
In the second of this series on healthy aging, we reveal how Scripps Research scientists are developing interventions to remove stiff, achy joints from the aging equation. This article is taken from the Summer 2021 of our award-winning Scripps Research Magazine. Show notes: Explore the Scripps Research Magazine https://magazine.scripps.edu/…
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Peer into the future of healthy aging. In this episode (the first of a 5-part series), we shed new light on how our cells and organs work together to influence longevity, and how newly discovered molecules may be able to block biological degeneration. This article is taken from the Summer 2021 of our award-winning Scripps Research Magazine. Show notes: Explore the Scripps Research Magazine https://magazine.scripps.edu/…
Dr. Ed Ramos is director of Digital Clinical Trials for the Scripps Research Digital Trials Center. Listen as we talk about empowering the individual with wearable health devices, the worst foods for spiking our blood sugar and the importance of lifelong flexibility. Show notes: PROGRESS study enrollment https://progress.scripps.edu/ PROGRESS study explainer video https://www.youtube.com/watch?v=UUdaMojHLuk&t=74s Ed’s bio https://www.scripps.edu/science-and-medicine/translational-institute/about/people/ed-ramos/ Scripps Research Digital Trials Center https://digitaltrials.scripps.edu/…
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1 Episode 24- Eric Topol & Andrew Ward: How Spike Protein Discoveries Drove Coronavirus Vaccine Design 35:35
Another special edition featuring an extended conversation between Dr. Eric Topol, Director of the Scripps Research Translational Institute, and Professor Andrew Ward in the Department of Integrative Structural and Computational Biology at Scripps Research. Listen as they talk about structural biology as a gamechanger in coronavirus research, what makes the SARS-CoV-2 spike protein crucial for vaccine design, and what the latest coronavirus mutations mean for the pandemic. Show notes: The Ward Lab: https://ward.scripps.edu/ Dr. Eric Topol’s bio: www.scripps.edu/faculty/topol/ Inside the Lab That Invented the COVID-19 Vaccine: https://www.youtube.com/watch?v=-92HQA0GcI8&%3Bfeature=youtu.be Solving the spike protein’s 3D structure: https://www.scripps.edu/newsandviews/e_20160307/ward.html Science, Simplified: How vaccines work against COVID-19 https://youtu.be/uWGTciX795o Scripps Research on social media: Twitter, Instagram: @scrippsresearch Facebook: @ScrippsResearchInstitute LinkedIn: the-scripps-research-institute…
Dr. Daphne Lurie is a California-licensed clinical psychologist and Director of the Counseling and Psychological Services (CAPS) on the Scripps Research La Jolla campus. Listen as we talk about the impact of the COVID-19 pandemic on mental health trends, using mindfulness to become more efficient and ziplining in Costa Rica. Show notes: Daphne’s Scripps Research profile: https://www.scripps.edu/about/campus-resources/counseling-and-psychological-services/about-us/ Counseling and Psychological Services (CAPS) at Scripps Research: https://www.scripps.edu/about/campus-resources/counseling-and-psychological-services/ Other mindfulness resources discussed: A Mindfulness-Based Stress Reduction Workbook - Bob Stahl, Elisha Goldstein The Mindful Self-Compassion Workbook - Kristin Neff, Christopher Germer…
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Stories brought to life! Today’s audio adventure comes from the Fall 2020 edition of our Scripps Research Magazine. We dive into the adaptations made by institute researchers during the COVID-19 pandemic to ensure both safety and continued scientific discovery. Show notes: Explore our Scripps Research Magazine and subscribe https://www.scripps.edu/news-and-events/connect-with-us/…
Dr. Kara Marshall is based in the Department of Neuroscience at Scripps Research, working as a postdoctoral researcher in Professsor Ardem Patapoutian’s lab. Listen as we talk about the circuitry involved in urination, burst bladders and improv comedy. Show notes: The Patapoutian Lab https://patapoutianlab.org/ Kara’s recent discovery on bladder function https://www.nature.com/articles/s41586-020-2830-7 Deciphering how the body’s cells sense touch https://www.nature.com/articles/d41586-019-03955-w Proprioception: the silent ‘sixth’ sense https://www.vox.com/the-highlight/2019/11/22/20920762/proprioception-sixth-sense…
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1 Episode 20 – Eric Topol & Dennis Burton: Antibodies, Vaccines and the Current State of COVID-19 45:06
Today’s special edition features an extended conversation between Dr. Eric Topol, Director of the Scripps Research Translational Institute, and Professor Dennis Burton, Chair of the Department of Immunology and Microbiology at Scripps Research. Listen as they talk about antibody cocktail treatments, the mystery of “longhaul” COVID-19 symptoms and how close we are to developing a coronavirus vaccine. Transcript of today's episode https://www.scripps.edu/covid-19/videos/topol-burton/index.html Dr. Eric Topol’s bio https://www.scripps.edu/faculty/topol/ Prof. Dennis Burton’s bio https://www.scripps.edu/faculty/burton/ Efficacy of convalescent plasma https://www.sandiegouniontribune.com/business/biotech/story/2020-08-30/hundreds-of-san-diegans-with-covid-19-have-already-been-treated-with-plasma-but-does-it-work “COVID longhaulers” https://www.theatlantic.com/health/archive/2020/08/long-haulers-covid-19-recognition-support-groups-symptoms/615382/ Coronavirus vaccine Q&A with Prof. Dennis Burton https://www.sandiegouniontribune.com/business/biotech/story/2020-07-26/q-a-an-update-on-the-race-for-a-covid-19-vaccine-scripps-research-immunologist-dennis-burton Dr. Eric Topol on social media: Twitter: @EricTopol Instagram: @erictopol1 Scripps Research on social media: Twitter, Instagram: @scrippsresearch Facebook: @ScrippsResearchInstitute LinkedIn: the-scripps-research-institute…
Dr. Amanda Roberts is the Senior Scientific Director of the Mouse Behavioral Core at Scripps Research. Listen as we talk about microgravity as a model of accelerated aging, NASA’s top-secret agents and what happens to slime in space. (Image Credit: Andrew Roberts) Show notes: Amanda’s research profile: https://vivo.scripps.edu/display/RobertsAmanda Replay of the NASA launch (action around ~11 minutes in): https://www.cnbc.com/2019/07/25/spacex-livestream-watch-the-company-launch-nasa-crs-18-on-a-falcon-9.html News coverage of the NASA mouse studies: https://www.nasa.gov/feature/ames/studying-behavior-in-space-shows-mice-adapt-to-microgravity https://qz.com/1597197/nasas-space-station-mice-loved-microgravity/…
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Science Changing Life
Research discoveries brought to life! In today’s segment, we explore Scripps Research’s Natural Products Discovery Center, a historic natural collection that may hold the key to thousands of future therapies. This article is taken from the Fall 2019 edition of our Scripps Research Magazine. Show notes: Digital version of our Fall 2019 magazine: https://issuu.com/endeavor-scripps-research/docs/magazine_fall2019_pageflipper?embed_cta=read_more&embed_context=embed&embed_domain=www.scripps.edu Subscribe to receive the Scripps Research magazine: https://signup.e2ma.net/signup/1879047/1890109/ The Scientist: Scripps Research acquires Pfizer’s massive microbial library https://www.the-scientist.com/news-opinion/scripps-acquires-pfizers-massive-microbial-library-66923 West Palm Beach News: Local organization works to create new medicine https://www.wpbf.com/article/local-organization-works-to-create-new-medicine-scripps-research-jupiter/30813823 The Shen Lab: https://www.scripps.edu/shen/…
Research discoveries brought to life! In today’s short story, we find out how medicines designed for our pets are now being repurposed by our scientists to provide a lasting, protective vaccine against Lyme disease. This article is taken from the Fall 2019 edition of our Scripps Research Magazine. Show notes: Digital version of the Scripps Research Fall 2019 magazine: https://www.scripps.edu/news-and-events/connect-with-us/magazine-current-issue/index.html Subscribe to receive the Scripps Research magazine: https://signup.e2ma.net/signup/1879047/1890109/ US News & World Report: The growth and reach of Lyme disease: https://www.usnews.com/news/healthiest-communities/articles/2019-12-10/lyme-disease-diagnoses-grow-in-private-insurance-claims…
David Biello is an award-winning journalist and the scientific curator for TED. Listen as we talk about his favorite areas of science, how to craft a compelling narrative and being obsessed with blind cavefish. Show notes: David’s profile at TED (and book link) https://www.ted.com/speakers/david_biello David’s work at Scientific American https://www.scientificamerican.com/author/david-biello/ TED talk – ‘Clues to prehistoric times, found in blind cavefish’ https://www.ted.com/talks/prosanta_chakrabarty_clues_to_prehistoric_times_found_in_blind_cavefish TED talk – ‘What happens in your brain when you taste food’ https://www.ted.com/talks/camilla_arndal_andersen_what_happens_in_your_brain_when_you_taste_food Social media: Twitter: @dbiello Remember to follow @ScrippsResearch on Twitter, Instagram, Facebook and LinkedIn…
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Science Changing Life
Dr. Kristen Johnson is a lead investigator at Calibr, the drug discovery division of Scripps Research. Dr. Maria Millan is the President and CEO of the California Institute for Regenerative Medicine (CIRM). Listen as we talk about the world’s largest stem cell bank, restoring healthy cartilage to patients, and the advantages of non-profit research. Show notes: Kristen’s talk in the Scripps Research Front Row Lecture Series https://www.youtube.com/watch?v=WRzQniqUlHo&t=1941s Coverage of KA34 in the San Diego Union Tribune https://www.sandiegouniontribune.com/business/biotech/sd-me-scripps-cartilage-drug-arthritis-20180624-story.html Maria’s profile at CIRM https://www.cirm.ca.gov/about-cirm/cirm-leadership Social Media: Follow @ScrippsResearch on Twitter, Instagram, Facebook and LinkedIn Follow CIRM on Twitter:@CIRMnews ; Instagram:@cirm_stemcells ; Facebook: @California InstituteForRegenerativeMedicine…
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Science Changing Life
1 Ep. 14–Brian Fiske & Jeff Kelly: Accelerating Discoveries to Treat Neurodegenerative Disease 18:50
Dr. Brian Fiske is the Senior Vice President for Research Programs at the Michael J. Fox Foundation for Parkinson’s Disease. Professor Jeff Kelly is in the Department of Chemistry at Scripps Research. Listen as we talk about biomarkers for early disease detection, the importance of long-term human trials, and how Parkinson’s disease could originate in the gut. Show notes: Dr. Fiske’s bio at MJFF https://www.michaeljfox.org/foundation/leaders.html?subcatid=381 Prof. Kelly’s bio at Scripps Research https://www.scripps.edu/faculty/kelly/ Coverage of FDA approval of Tafamidis https://www.scripps.edu/news-and-events/press-room/2019/20190506-fda-approved-tafamidis.html https://www.fda.gov/news-events/press-announcements/fda-approves-new-treatments-heart-disease-caused-serious-rare-disease-transthyretin-mediated Social Media: Twitter/Instagram: @MichaelJFoxOrg Remember to follow @ScrippsResearch on Twitter, Instagram, Facebook and LinkedIn…
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Science Changing Life
Dr. Eric Topol is the Founder and Director of The Translational Institute at Scripps Research. Listen as we talk about bringing back empathy in medicine, smartphone ultrasounds and the best media for absorbing scientific information. Show notes: Translational Institute at Scripps Research https://www.scripps.edu/science-and-medicine/translational-institute/ Eric’s new book: Deep Medicine https://www.amazon.com/Deep-Medicine-Artificial-Intelligence-Healthcare/dp/1541644638 Current and future applications of technology in healthcare https://www.nature.com/articles/s41591-018-0300-7.pdf The Topol Review on the future of the NHS https://topol.hee.nhs.uk/ Eric’s 2016 Tedx Talk https://www.youtube.com/watch?v=y9nS1b7ifSE Twitter: @EricTopol Facebook: @ScrippsRTI Instagram: @erictopol1…
Dr. Chatterjee is the Vice President of Medicinal Chemistry at Calibr, the biotechnology division of Scripps Research. Listen as we talk about re-purposing existing compounds for new diseases, the future of robotics in drug discovery and our favorite Superheroes. Show notes: About Calibr https://www.scripps.edu/science-and-medicine/calibr/about/index.html ReFRAME Initiative https://www.scripps.edu/news-and-events/press-room/2018/20181003-reframe-calibr.html Footage of Calibr’s robots in action https://www.statnews.com/2018/12/10/calibr-drug-compounds-mined-new-treatments/ Use of the ReFRAME library to treat Cryptosporidium infection https://www.pnas.org/content/115/42/10750…
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Science Changing Life
Matthias is based in the Department of Immunology and Microbiology at Scripps Research, working in Prof. Kristian Andersen’s Lab. Listen as we talk about wearable devices to monitor disease progression, research field-trips to West Africa and fancy nights at the symphony. **p.s. if you enjoyed the Christmas jingle, Matthias and I are currently working on an album** Show notes: Andersen Laboratory https://andersen-lab.com/ CViSB Consortium https://cvisb.org/ Burton Laboratory https://www.scripps.edu/burton/ @mpauthner on twitter @cvisb on twitter @mattmirabilis on Instagram…
Alyssa is based in the Department of Molecular Medicine at Scripps Research, under the supervision of Prof. Joseph Kissil. Listen as we talk about cancer biology, naked mole-rats and practical tips for improving science communication. Show notes: Kissil Laboratory https://www.scripps.edu/kissil/ Alyssa’s blog https://thecurioussheep.net/blog/ @the_curioussheep on Instagram @_curioussheep on twitter…
Prof. Miller is based in the Department of Molecular Medicine at Scripps Research. Listen as we talk about methamphetamine-use disorder, short- and long-term memory formation, and Breaking Bad. Show notes: Prof. Miller’s Scripps Research bio https://www.scripps.edu/faculty/miller/ Pearson Center for Alcoholism and Addiction http://www.pearsoncenter.org/laboratories-pearson-center/ News coverage of recent work https://eurekalert.org/pub_releases/2018-09/sri-ouc091418.php @millerlab3 on twitter…
A compilation of interview highlights recorded live from the branding launch party at Scripps Research. I heard from scientists about how their work is changing life, and spoke with members of communications/marketing/philanthropy about what this new brand means for the institute and the wider community. Show notes: Scripps Research Community Events Calendar https://www.scripps.edu/news-and-events/events-calendar/ How To Connect With Scripps Research https://www.scripps.edu/news-and-events/connect-with-us/ “All of Us” Research Program at the Scripps Research Translational Institute https://www.scripps.edu/news-and-events/press-room/2018/20180501-medicine-all-of-us.html Calibr at Scripps Reseearch https://www.scripps.edu/science-and-medicine/calibr/ Grizzly Marketing Team https://madebygrizzly.com/…
Prof. Gary Siuzdak is the Director of the Metabolomics Center at Scripps Research. Listen as we talk about using our own metabolites to impact health status, environmental estrogen-mimics and the potential benefits of Red Bull. Show notes: Metabolomics Center website https://masspec.scripps.edu/landing_page.php?pgcontent=mainPage Gary’s VIVO Scientific Profile https://vivo.scripps.edu/display/SiuzdakGary News coverage of xenoestrogen work https://www.sciencedaily.com/releases/2018/01/180111155106.htm https://www.telegraph.co.uk/science/2018/01/11/breakthrough-breast-cancer-drug-thwarted-chemical-found-bread/ News coverage of oligodendrocyte work https://www.eurekalert.org/pub_releases/2017-12/sri-tlh120817.php…
Dr. Peterson is an Assistant Professor in the Department of Nutrition Sciences at the University of Alabama at Birmingham. Listen as we talk about different fasting strategies, the big bang and the importance of our biological rhythms. Show notes: Dr. Peterson’s UAB Bio https://www.uab.edu/shp/nutrition/about-the-department/faculty-and-staff/primary-faculty/160-courtney-m-petersonProject Time Restricted-Feeding Blog Post http://blog.mycircadianclock.org/early-time-restricted-feeding-for-the-prevention-of-diabetes/ Dr. Peterson’s Coverage in the Washington Post https://www.washingtonpost.com/national/health-science/timing-your-meals-may-help-with-weight-loss-thats-what-it-seems-to-do-in-mice/2018/03/23/14672fc0-f718-11e7-a9e3-ab18ce41436a_story.html?noredirect=on&utm_term=.af64ab9e5818 Dr. Peterson’s Pilot Study of TRF in Prediabetes https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30253-5…
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Science Changing Life
Tod Williams and Billie Tsien are the architects responsible for designing what was formerly the Neurosciences Institute (NSI); the buildings now make up the Hazen Campus and serve as the focal point of The Scripps Research Institute. Listen as we talk about the history of the build, common motifs for all science buildings and the importance of afternoon tea. Show notes: Tod Williams and Billie Tsien bios http://www.twbta.com/studio/people/tod-williams-billie-tsien Project Images of the building complex http://www.twbta.com/6675 2017 LongHouse Award https://www.archdaily.com/805628/tod-williams-plus-billie-tsien-win-2017-longhouse-award-discuss-design-ideas-for-obama-presidential-library 2013 National Medal of Arts Award https://www.arts.gov/honors/medals/billie-tsien-and-tod-williams In memoriam: Gerald Edelman https://www.scripps.edu/newsandviews/e_20140602/edelman.html…
Steve is the Director of Digital Medicine at the Scripps Translational Science Institute (STSI). Listen as we talk about Fitbits, perverse healthcare incentives and hiking to Mount Everest Base Camp. Show notes: Steve’s bio at STSI https://www.stsiweb.org/about/faculty/steinhubl-steven/ STSI Precision Medicine Initiative https://www.stsiweb.org/translational-research/precision-medicine-initiative/ DIGIMED 2017 conference program https://www.stsiweb.org/event/digimed17/digimed17-program/ Nature Digital Medicine Journal https://www.nature.com/npjdigitalmed/…
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Science Changing Life
Matt is the Vice President of Business Development at TSRI, as well as Chief Operating Officer at Calibr. Listen as we talk about what constitutes commercially valuable research, why TSRI is #1 for science innovation and how to design a home jungle gym. Show notes: Matt’s recent Biocom Catalyst Award http://www.scripps.edu/newsandviews/i_20171002/20171002tremblay_biocom.html?utm_source=newsviews&utm_medium=email&utm_campaign=internal20171002 Calibr Bio http://www.calibr.org/about/institute-leadership/ TSRI-Calibr partnership https://www.eurekalert.org/pub_releases/2016-10/sri-tac102016.php…
Arthur is based in the department of integrative structural and computational biology at TSRI. Listen as we talk about HIV modelling, hexbug toys and human avatars. Show notes: Olson Lab website http://mgl.scripps.edu/ HIVE center http://hive.scripps.edu/ 3D printed demo of viral self-assembly https://www.youtube.com/watch?v=br-YxeXWx6s AR + 3D models to understand molecular interfaces https://www.youtube.com/watch?v=gZxK6j4JTHQ…
Formerly of TSRI, Lynda is now part of a local start-up. Listen as we talk about industry pros and cons, endurance athletics and Richard Branson. Show notes: Abilita Bio company website http://www.abilitabio.com/ Biotechnology and networking resources SDBN – San Diego Biotechnology Network http://sdbn.org/ LSN – Life Science Network http://lifesciencenetwork.com/home SDEE – San Diego Entrepreneurs Exchange http://www.sdentrepreneurs.org/ FBB – French Bio Beach http://frenchbiobeach.com/ WIB – Women In Bio http://www.womeninbio.org/ CLSA – California Life Science Association http://califesciences.org/ Two Scientists Walk into a Bar http://www.rhfleet.org/events/two-scientists-walk-bar Suds and Science http://www.rhfleet.org/events/suds-science Spotlight on JLABS http://jlabs.jnjinnovation.com/…
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